Introduction: Frustration and emotion dysregulation have been among the most factors contributing to suicidal tendencies faced currently by societies. Therefore, developing a training program to decrease such tendencies seems necessary. This study aimed to investigate the effectiveness of an integrative intervention in decreasing frustration and emotion dysregulation as determinants of suicidal tendencies among adolescents and young people. Materials and Methods: The present study is an experimental trial with a pretest-posttest design and control group and was conducted on 40 adolescents and young persons aged 15-25 who were selected through the random cluster sampling in 2018-19 in Ilam. All of the participants completed the Suicide Attitude Questionnaire, Children's Health Locus of Control Scale(CHLC), and Cognitive Emotion Regulation Questionnaire (CERQ-P). The experimental group received an integrative intervention, while the control group received no intervention. Upon the completion of the intervention and collecting the data, they were analyzed using multivariate covariance analysis (MANCOVA) and by SPSSV22 software. Results: The results of multivariate analysis of variance showed that there is significant difference in the scores of the two groups (Wilks' lambda=0. 251, F=5. 664, p=0. 001) in terms of despair (F=6. 843, p=0. 013), self-blame (F=10. 412, P=0. 003), rumination (F=5. 016, p=0. 031), catastrophizing (F=6. 331, p=0. 016), blaming others (F=14. 132, p=0. 001), positive re-focus (F=9. 126, p=0. 005), planning re-focus (F=10. 275, p=0. 003), and positive re-evaluation (F=6. 024, p=0. 019). However, there was no significant intergroup difference in terms of acceptance (F=0. 830, p=0. 368) and perspective taking (F=0. 121, p=0. 730). Conclusion: Organizing training programs based on an integrative approach has been effective in decreasing despair and emotion dysfunction among the adolescents and young people with suicidal tendencies. Conducting training programssuch as problem-solving, emotional, regulation, mindfulness, etc. for psychologists, parents, adolescents, health professionals, and social pathologists can be effective in decreasing and preventing suicide among adolescents.