In a field study, the effects of different amounts of municipal solid waste compost and nitrogen on cotton characteristics and chemical properties of soil were studied. The statistical design was split plot. Different levels of municipal solid waste compost (0, 20 and 40 t ha-1) were considered as the main factor and different levels of nitrogen (0, 100 and 200 kg ha-1) were considered as sub plots. The results of the experiment showed that the effects of municipal solid waste compost, the effect of nitrogen and their interaction on cotton yield and qualitative properties of the fibers are significant. Municipal solid waste compost and nitrogen, each alone, increased yield, but the highest yield was 4787 kg ha-1 from municipal solid waste compost consumption of 40 tons per hectare with 100 kg / ha nitrogen per hectare. Consumption of more nitrogen at this level of compost did not have a significant effect on yield. Consumption of municipal solid waste compost had a significant effect on the chemical properties of soil, so that, with the use of municipal solid waste compost waste compost, soil reaction (pH) decreased significantly and the values of electrical conductivity, organic carbon, nitrate, available iron and zinc showed a significant increase. Therefore, in the same conditions, in order to achieve maximum yield, 50% reduction in nitrogen fertilizer consumption and improvement of qualitative characteristics of cotton fibers, increase of soil organic matter and uptake of nutrients absorbed in soil, consumption of 40 tons per hectare of municipal solid waste compost with 100 kg Nitrogen per hectare was recommended.