In the long-run vision, the industry and mining sector is considered as the engine of continuous, stable and accelerated economic growth, but the Iranian economy has been facing exchange rate volatility over the past few decades, which has affected the industry sector. Exchange rate volatility can affect the production, investment, employment and price behavior of industrial firms from various channels. Therefore, the recognition of these channels can determine the mechanisms of the effect of exchange rate volatility on the industry sector. Accordingly, the main object of this research is analyzing the effects of exchange rate volatility on the value-added of the industry and mining sector in Iran under sanction, that the sanction is included in the research by entering the dummy variable into the model. The model is estimated using the Auto-Regressive Distributed Model for the period 1968-2017. The results of long-term estimates indicate that severe sanctions through exchange rate volatility will have a negative and significant effect on the growth of value-added of the industry and mining sector. Also, the growth rate of capital accumulation, the growth rate of the labor force, the growth rate of bank lending facilities and the growth rate of import of capital goods in the industrial and mining sectors have positive and significant effects on the value-added of the mining and industrial sectors.