Background and Aim: Increasing population and urbanization density and as a result, increasing impermeable surfaces, has led to an increase in the volume of urban runoff. Applying simulation models is a suitable way to know the runoff quality parameters. This study aimed at evaluating the quality of urban runoff in Shushtar city using the Storm Water Management Model (SWMM). Materials and Methods: Two given rainfall events in 2016 were considered for calibration and validation of the model. The parameters related to the first rainfall event were measured at the outlet of the urban drainage system. The quantitative and qualitative calibration of the model was performed using the data of the first rainfall and model validation was performed using the data of the second rainfall. Results: In the hydraulic calibration, the mean values of impermeability, slope, catchment width, and Manning’ s coefficient were estimated to be 50%, 75%, 25 m, and 0. 013, respectively. In the qualitative calibration, the coefficients of the Build-up equations for TSS, COD, and Zn were equal to 95-25, 48-1, and 1-0. 09, respectively. The coefficients of Wash-off equations for TSS, COD, and Zn were estimated at 0. 21-0. 8, 0. 2-0. 8, and 0. 19-0. 78, respectively. Conclusion: The results showed that the accurate calibration of the model enhances the ability of the model to estimate the quantitative and qualitative parameters in future rainfall events for the study area. According to the results, modeling is a powerful tool that can be very useful to improve runoff management.