Since the outbreak of the Islamic Revolution and the fundamental changes in Iran's foreign policy, the differences between the Islamic Republic and the United States have started in various dimensions, and in recent years, with new challenges added. The threats of the United States, with regard to the country's ruling attitude and regional conditions, include a variety of dimensions that have been tried and tested in all its dimensions with a futuristic approach. For this purpose, trend analysis has been used as one of the main methods of futures research. This research is applied in the applied research group and in terms of its method in the case study group. In addition, in the method of analysis, the qualitative approach and background analysis have been used. In order to achieve the research objectives, the present study deals with the descriptive analysis of USA threats against Islamic Republic of Iran in strategic documents published (between 2005 and 2017), As well as categorizing threats and reviewing their content. In the second part of the research, while analyzing the process of extracted threat strategies, the future trends of threats in the dimensions of regional, political, economic, security, social and thought, cyber and cultural have been discussed.