Sources of renewable energy are a major global concern for researchers. In recent years, the generation of thermoelectric power from waste heat has appeared as a green and clean energy competitor. Beyond the linear response regime, nonlinear thermoelectric phenomena such as negative differential thermoelectric resistance (NDTER) and thermoelectric rectification constitute a new area of research, anticipated to enhance thermoelectric response. Organic thermoelectric materials (TM) have emerged as superior TMs, since they are non-toxic, ecofriendly, and low-cost. Herein, bio-organic materials provide a unique opportunity in developing bio-degradable, flexible and smart TM. In this work, we describe nonlinear phononthermoelectric DNA-based nano devices driven by temperature biases. Remarkably, we found that by applying a temperature difference between the source and the drain, the sensible electric current is generated. The temperature of hot thermostat and the temperature bias are considered as a control parameter. By modulating the temperature bias, NDTER phenomenon can be achieved. NDTER is used to refer to a phenomenon in which the charge current decreases by increasing the temperature bias. Moreover, by fixing the temperature bias between cold and hot reservoirs and varying the temperature of hot reservoir, the charge currents are different for the forward and reverse direction of ∆ T. This is what is called a thermoelectric rectification.