Background and Objectives: Approperiate treatment of obstructive uropathy is a disease is of great importance in patient care. The objective of this study was to compare the results and complications of percutaneous nephrostomy with hemodialysis in correcting water and electrolyte disorders in patients with obstructive uropathy. Subjectes and Methods: In this clinical trial study, 30 patients with obstructive uropathy were selected as study group. Patients were randomly divided into hemodialysis and percutaneous nephrostomy (PCN) groups. In both groups, BUN/Cr, Na, and K were measured every 6 hr. The end point variables were: time for preparation for action (T1), time to clearance (T2), total hospitalization time (T3), pain score, satisfaction rate and complications in both groups were compared. Finally, the data were analyzed using SPSS software versin 20. Results: Results shows that T1 in both PCN and hemodialysis groups was not significantly different. However, T2 and T3 in the PCN group had was more significantly decreased than in hemodialysis group. In addition the satisfaction rate in patients with PCN was higher than hemodialysis. Concentration of potassium and creatinine in the PCN group decreased more than hemodialysis. However, there was no significant difference in the trend of reduction of other indicators such as sodium, systolic and diastolic blood pressure in both groups. Conclusion: PCN method can be an alternative, appropriate, less expensive, and has fewer complications than hemodialysis method for patients with obstructive uropathy.