The decision making in romantic relationships, such as to start dating, marriage proposal, or ending a relationship, can have long-lasting and important consequences. This study was conducted to aim the effectiveness of Premarital Interpersonal Choices and Knowledge Program (PICK) on decision making in mate selection of single students with a quasiexperimental research design to pre-test and post-test and control group. 36 single students were selected voluntary and on 1 score of standard deviation lower than the mean in Relationship Decision-making Scale and inclusion/ exclusion criteria, and were assigned randomly to a experiment group (n = 18) and a control group (n = 18). The participants completed the relationship decision-making scale in two stage of pre-test and post-test. The experiment group participated in 9 sessions, twice a week, 90 minutes each, in a Premarital Interpersonal Choices and Knowledge Program (PICK). The findings indicated that Premarital Interpersonal Choices and Knowledge Program (PICK) has led to increase awareness of relationship decisionmaking in experimental group rather than in control group. Therefore, the Premarital Interpersonal Choices and Knowledge Program is a appropriate method to improve decision-making in mate selection.