Background & Purpose: Requiring appropriate prerequisites, identification and exploitation of existing opportunities can lay the foundations for the continuous improvement of organizational performance. This study analyzes the mediating role of organizational entrepreneurship in the effect of organizational innovation on organizational performance. Methodology: This is an applied descriptive-correlational study, in which the statistical population includes the directors and experts of Bank Keshavarzi Iran in Tehran Province. The simple random sampling method was employed to select 292 participants as the statistical sample. A standard questionnaire was used for data collection. The Kolmogorov-Smirnov test and the correlation test were then conducted for hypothesis testing, whereas the path analysis was employed to analyze the causal relationships between the research variables. Findings: There is a positive correlation among organizational innovation, organizational entrepreneurship, and organizational performance. Moreover, organizational innovation improves organizational performance by facilitating and accelerating organizational entrepreneurship. Conclusion: Promoting innovation in products, processes, and technologies will improve the leading role, risk-taking capacity, and competitiveness of organizations. Therefore, organizational performance indices will improve.