In order to evaluate the effects of soil fertilizers and summer irrigation on corm, flower and stigma yield of saffron, an experiment was conducted as factorial based on a randomized complete block design with three replications at the Agricultural Research station, Ferdowsi University of Mashhad during three growing seasons of 2013-2016. The first factor included cow manure, chemical fertilizer (N, P and K), Thiobacillus spp., sulfur, Thibacilus + sulfur and control and the second factor was summer irrigation in three levels including without summer irrigation, once summer irrigation (23 July) and twice summer irrigation (22 June+23 July) in the second and the third years. The results in the third experiment (2015-2016) revealed that the interaction effect between soil fertilizers and summer irrigation were significant (P≤ 0. 01) on all studied traits except stigma dry weight, corms with weight more than 16 g and dry weight of daughter corms. The highest flower number (282. 7 numbers. M-2), flower fresh weight (103. 2 g. m-2), stigma dry weight (1. 73 g. m-2), leaf dry weight (13. 33 g. m-2), dry weight of buds (4. 61 g. m-2), number of flowering buds per corm (2. 627), corm percentage with contractile roots (%58. 41), corm diameter (3. 61 cm) and corms in different weights were obtained in cow manure and once summer irrigation. It seems that summer irrigation has caused promotion of the release of nutrients of cow manure and these nutrients are provided gradually during the growth of plants.