Small and medium-sized organizations are considered as the engine of economic development and employment. The share of small and medium-sized organizations for more than 95% of businesses is creating 50% of value added worldwide and depending on the country, production between 60% to 90% of all new jobs. The present paper, with examining the information obtained from 73 small, medium-sized manufacturing enterprises, studied the relationship between information sharing in the supply chain and innovation performance of the organization by considering factors such as quality management and supplierspecific investment. In this study, 4 main hypotheses regarding the relationship between chain information sharing, supply of quality management, supplierspecific investment, and the effect of relationship between quality management and supplier-specific investment on innovation performance of the organization have been examined. The results of the study indicated that information sharing in the supply chain has a positive and direct effect on quality management and supplier-specific investment. The results also showed that the impact of information sharing in the supply chain on the specific investment of the supplier is higher than its impact on quality management. Finally, the impact of quality management on organizational innovation performance is far greater than the impact of supplier-specific investment on organizational innovation performance.