Background: This study examined the effectiveness of cognitive behavior therapy on depression and anxiety improve learners. Methods: Using a quasi-experimental design Seventeen employees of Kish Free Zone Organization in accordance with criteria Psychiatric Association America were diagnosed with generalized anxiety and depression and were divided into two experimental and control groups. The experimental group were sixteen individual sessions of cognitive behavioral therapy. At the end of treatment and after three months of treatment, participants were re-evaluated. Results: The results showed that CBT significantly improved depression and generalized anxiety disorder at post-test and follow-up points. Conclusion: The results showed that CBT is effective in reducing symptoms of depression and anxiety.