Background and Objectives: This study aims to investigate the relationship between the rate of cardiovascular and respiratory death and the average concentration of major air quality index "AQI” , including NO2, SO2, CO, O3 and PM10 in Ahvaz city, Khozestan, Iran, in the period of 10 years. Subjects and Methods: This retrospective analytic study was conducted in Ahvaz city in 2019, based on referrals and the number of cardiovascular and respiratory patients through HIS system (Hospital Information System) and air pollutants were obtained and air quality monitoring stations in Ahvaz, respectively. The data were analyzed by SPSS and Poisson Distribution Regression Model to evaluate the effects of each pollutant and the rate of hospitalization. Results: Based on the results, there was a significant relationship between the average concentration of NO2, O3, CO and SO2 and hospitalization of patients with cardiovascular disease (P value<0. 05) that the case with NO2 more than other pollutants. Furthermore, there was a significant relationship between the average concentrations of NO2, CO and PM and the hospitalization rate of patients with respiratory problems (P value<0. 05). Also, the effects of NO2 was higher than other pollutants. Conclusion: The findings of this study demonstrated that exposure to air pollutants, especially NO2, can predispose to higher risk of deaths due to cardiovascular and respiratory complications. Therefore, reducing the concentration of these pollutants can reduce the number of these types of deaths.