The purpose of this study was to optimize the operational parameters of the electrical discharge machining (EDM) process in the Inconel 718 super alloy using the Taguchi method and analysis of variance (ANOVA). First, using Taguchi method, the optimal order of experiments was determined, and then by performing experiments and analysis of variance, the effects of the contribution of each input parameter on the process output were determined, and finally the optimal input parameters were determined. Input parameters in this study included pulse duration, work factor, gap voltage and discharge current. Furthermore, process output parameters, electrode wear ratio, material removal rate and topography of the sample surface were taken into consideration. From the surface topography point of view, items such as surface roughness, recast layer thickness and crack density of machined samples were studied in detail. In addition, modeling and regression analysis was performed to predict the behavior and values of process output parameters. The results of optimizing the operational parameters of the process indicated less electrode wear, better surface roughness and homogeneous and crack-free microstructure compared with the behavior of the Ti-6Al-4V alloy.