Introduction: The level of empathy, commitment, respect to clients and receiving feedback from health service outcomes in the health system staff are lower than the expected quality. The Sound-Heart spiritual care model considers the patients care and treatment as the highest worship. Providing health services requires cultivating, deepening spirituality and spiritual empowerment of medical students. The purpose of this study was to design and validate the Students' Spiritual Self-care empowerment model with sound heart approach. Methods: By using the philosophical inquiry and the conceptual analysis approach and Qualitatively-Derived Theory based on Morse et al. 's Concept-Integration method, students' spiritual empowerment model was designed in six stages: defining concepts representing the main phenomenon, level of concept development, relationship between concepts, detailing the central concepts to determine the relationship between them, and formulating conceptual model. The findings robustness, accuracy, completeness, comprehensibility, clarity and rationality, were confirmed by Morse's suggestions, the use of authentic Islamic texts, and three specialized panels, by faculty members of the Academy of Spiritual Health. Results: Conceptual model elements included: students' confidence building, spiritual knowledge-building, development of relationship with God, self, people and creatures, motivation, self-confidence and "self-efficacy". Daily self-calculation based on the problem-solving process is needed. Professors should avoid students' inquisition. As mentors, they should train the student by cultivating themselves. Conclusion: Considering the cultural and educational challenges in Iranian universities and the necessity of spiritual education of students, the spiritual empowerment model is suggested as an executive strategy.