Purpose: A case report of a patient with endogenous endophthalmitis following acute cholecystitis. Case Report: a 64-year-old woman without medical history underwent uncomplicated cataract surgery due to a mature cataract and was discharged with essential recommendations. A few hours later, she was admitted to the hospital because of acute abdominal pain, and with the diagnosis of acute cholecystitis, cholecystectomy was done and intravenous antibiotic therapy was started. On a postop day, 1 frequent prophylactic topical antibiotic and steroid was started but 3 days later, the patient’ s eye was visited at the clinic with the signs of fulminant acute endophthalmitis and total corneal melting. Intravenous, intravitreal, and topical antibiotic therapies started for the patient after admission as endogenous endophthalmitis, but unfortunately, the infection was unresponsive to treatment and the eye was lost. A week later, evisceration was done for the patient. Conclusion: Endogenous endophthalmitis is an uncommon type of endophthalmitis and the early diagnosis and treatment are important for the patient both visually and vitally.