Effect of Intravitreal Bevacizumab with Vitamin D Ssupplementation on Diabetic Macular Edema in Vitamin D Deficient Patients

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

FEKRI S.; Roozdar S.; SOHEILIAN M.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: BINA Year:2020 | Volume:25 | Issue:3 Page(s): 174-180

Download Full-Text

Persian Verion

View:

195

Download:

Cites:

Information Journal Paper

Title

Effect of Intravitreal Bevacizumab with Vitamin D Ssupplementation on Diabetic Macular Edema in Vitamin D Deficient Patients

Author(s)

FEKRI S. | Roozdar S. | SOHEILIAN M. | Issue Writer Certificate

Keywords

Diabetes Mellitus (DM)Q1

Diabetic Macular Edema (DME)Q1

BevacizumabQ1

Vitamin DQ1

Abstract

Purpose: To determine the effect of intravitreal injection of Bevacizumab (IVB), which is the standard treatment for diabetic macular edema, along with Vitamin D supplementation, on diabetic macular edema in patients with Vitamin D deficiency. Methods: Generally, 83 eyes of 83 patients with diabetes mellitus (DM) type 2 and diabetic macular edema (DME) were studied. The patients were divided into 3 groups: normal Vitamin D levels + IVB administration (Group 1, n=29), Vitamin D insufficient/deficient + IVB administration (Group 2, n=26), and Vitamin D insufficient/deficient + IVB administration+ oral Vitamin D supplementation (Group 3, n=28). All groups received 3 monthly IVB injections and group 3 received oral Vitamin D supplementation simultaneously. The patients were followed up 1, 3, and 6 months after the third baseline IVB with clinical examination, CDVA, and CMT measurements. Results: The mean baseline CDVA (LogMAR) in groups 1, 2, and 3 was 0. 68 ± 0. 16, 0. 72 ± 0. 14, and 0. 71 ± 0. 1, respectively. In months 1, 3, and 6, after the basic triple IVB injection, visual acuity improved in all groups, but the increase in visual acuity in month 6 was statistically significant in the group treated with Vitamin D supplement (group 3) and the group with normal Vitamin D levels (group 1) compared to the Vitamin D deficiency untreated group (group 2) (P<0. 001). Mean CMT decreased in all groups following IVB injections (466. 83 ± 57, 527. 46 ± 42. 3, and 500. 61 ± 56. 01 microns in groups 1, 2, and 3, respectively), but similar to visual acuity, only in month 6, these changes were significantly different in groups 1 and 3 compared to group 2 (P<0. 001). Conclusion: The correction of Vitamin D deficiency in DME patients with type 2 diabetes and Vitamin D deficiency, in addition to IVB injections, may play a role in improving CDVA and CMT.

Cites

No record.

References

No record.

Cite

APA: Copy

FEKRI, S., Roozdar, S., & SOHEILIAN, M.. (2020). Effect of Intravitreal Bevacizumab with Vitamin D Ssupplementation on Diabetic Macular Edema in Vitamin D Deficient Patients. BINA, 25(3 ), 174-180. SID. https://sid.ir/paper/415142/en

Vancouver: Copy

FEKRI S., Roozdar S., SOHEILIAN M.. Effect of Intravitreal Bevacizumab with Vitamin D Ssupplementation on Diabetic Macular Edema in Vitamin D Deficient Patients. BINA[Internet]. 2020;25(3 ):174-180. Available from: https://sid.ir/paper/415142/en

IEEE: Copy

S. FEKRI, S. Roozdar, and M. SOHEILIAN, “Effect of Intravitreal Bevacizumab with Vitamin D Ssupplementation on Diabetic Macular Edema in Vitamin D Deficient Patients,” BINA, vol. 25, no. 3 , pp. 174–180, 2020, [Online]. Available: https://sid.ir/paper/415142/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops