Childhood as one of the fundamental stages of human life can be accompanied with various harms in a way that it is more evident in children with chronic diseases, since these children cannot meet their needs, they need the people around them and caregivers, especially parents to help them with their situation, but unfortunately, they sometimes face neglect, ignorance, and limited access to health care services, poverty, violence, etc., which can be a source of frustration and intolerance of disease for them. Thus, the present qualitative research, aimed to protect the right of health for sick children and based on jurisprudential and legal documents, deals with describing and analyzing the causes and effects of despair in children with chronic diseases and strategies to prevent it. Grounded upon the juridical principle “ a possible part must not be abandoned by an impossible whole” , this study shows that providing suitable conditions and environment for sick children as much as possible is essential; Therefore, since various causes such as insufficient endowment of a decent standard of living, disregard for spiritual values and a tendency to be negative can affect the health and progression of children's illness, in the holy Sharia of Islam, based on the principle of respect for innate dignity of man, equal treatment and observance of the child’ s best interest, using hope therapy strategies in promoting spiritual health, as the cornerstone of other forms of health, is emphasized, which does not only require the participation and cooperation of the government, society, family and even sick children, but also needs more coherent laws and regulations in line with Islamic jurisprudence.