Introduction: Neuroblastoma is the most common extra cranial solid tumor in children, accounting for approximately 6-10% of all childhood malignancies. Survival rate in neuroblastoma depends on some variables such as the stage of the disease and children’s age. In the past decades, the incidence of neuroblastoma has increased and prognosis of the patients has improved. Method & Material: A historical cohort study was done. All children who were admitted in Isfahan university hospitals with the pathologic diagnosis of neuroblastoma during 1991 to 1999 were included in the study. 52 patients were available for follow-up and the median observation time was 80 months. Survival rate was analyzed by using life-table methods. Results: The patients were 52 (27 boys and 25 girls) with an average age of 4.5 years. At the time of the study, 22 of the patients were not alive. The median survival rate at 80 months from diagnosis for stages II, III and IV were 100%, 60% and 37%, respectively (p<0.0001). Frequency and percentage of the patients in stages I, II, III, IV and IV-S were 0, 9 (17.3%), 13 (25%), 29 (55.8%) and 1 (1.9%), respectively. Conclusion: The results suggest improvements in prognosis of children with neuroblastoma and it confirms the results of previous researches. Comparison of the survival rates of stages II, III and IV, show that, the patients’ survival rates are inversely correlated with their tumor stages. There is no significant relationship between the survival rate, sex and treatment procedures.