Hormozgan Medical Journal
Year:2003 | Volume:7 | Issue:1|Papers Count:14

Introduction: The presence of Thromboembolic complications in arteriovenous vessels in antiphospholipid syndrome promoted us to undertake a study to find the relationship between Helicobacter pylori (H. pylori) and cytomegalovirus and their complications, and also to determine if the involvement mechanisms are similar to those which are involved in coronary artery vessels. This study was performed to find infective and inflamatory factors role in thrombosis of antiphospholipid syndrome. This proof could lead to appropriate preventive as well as therapeutic measures. Method & Material: In this case-control study, 30 patients (25 females and 5 males) with definite diagnosis of antiphospholipid syndrome were included. This group of patients was compared with a control group consisting of 45 healthy cases and antibody production against H. Pylori and cytomegalovirus was assessed in all cases using the ELISA immunofluorescent method. Results: In 30 cases with antiphospholipid syndrome whose H. Pylori antibody production was checked, 13 cases showed a positive (43.3%) result where as in the control group, this increase was observed in 66.7% (P<0.045). With respect to cytomegalovirus antibody production, in the case-group, 15 cases were positive (50%) while in the control group this figure was 73.3% (P<0.039). Conclusion: The results of this study demonstrate that in cases with antiphospholipid syndrome, the level of antibody production to H. Pylori and cytomegalovirus is less than in healthy subjects and there is a negative relationship between these two organisms and the thrombosis observed in this syndrome.

Introduction: Quadriceps femoris angle (Q-angle) is the angle between the quadriceps load vector and patellar tendon load vector. It is shown that individual with Q-angle more than 15 degrees would display an increase in rear foot eversion and tibial internal rotation. The purpose of the present study was to determine the Q-angle in children and adults in Bandar Abbas, Iran. Method & Material: In this cross-sectional study, a random sample of 399 first year primary school pupils and third year high school students, with no history of knee disorders were selected. The right Q-angle was measured goniometrically with subjects standing in an erect position. The results were analyzed by using ANOVA and t-test statistical methods where p<0.05 was considered as significant. Results: Mean Q-angle in 7 years pupils was significantly lower than that from 17 years old students (9.27 vs. 10.65, p<0.0001). No difference in mean Q-angle was found between 7 years old male and female pupils, whereas, it was significantly different in 17 years old male and female students (p<0.001). Conclusion: Q-angle in this study was lower than that from other studies in the literature. This may probably be due to high incidence of genuvarus in Bandar Abbas.

Introduction: The main sources of Aluminum are foods, water, air and some medications like antacids. One of the side effects of antacid is constipation, which is caused by gastrointestinal motility reduction. Aluminum is known as a potent and irreversible calcium inward current blocker in some mammalian neurons. On the other hand, potassium chloride (KCl), oxytocin (OT) and acetylcholine (Ach) are well known to induce uterus contraction, so, in the present study we have investigated the effect of aluminum chloride on uterine contractions induced by these three stimulants. Method & Material: In this descriptive study the uterus of 24 mature virgin rat was removed from abdomen and mounted in an organ bath containing Tyrone solution (37˚C, 7.3-7.4 PH), bubbled with oxygen. Uterine contractility was recorded isometrically under 2g initial tension. After equilibrium period (60min), the percentage of changes in uterine contractility induced by KCl (1-5 mg/ml), oxytocin (0.001-100μg/ml) and acetylcholine (0.001-100 μg/ml) were recorded. The results were analyzed by using t-test and ANOVA statistical methods and P<0.05 was considered as significant. Results: The results indicated that, KCl, OT and Ach enhance the uterine contractility. The uterus contractions induced by KCL, OT and Ach were also inhibited by aluminum chloride dose-dependently (P<0.0001). Conclusion: From the obtained results we concluded that, aluminum chloride possibly inhibits KCl, oxytocin and acetylcholine stimulatory effect via blockade of the voltage dependent calcium channels.

Introduction: Iron defiency is the most common nutritional deficiency in children and one of the most important problems in general health care. Although the program of iron supplementation in Iran is for 6-24 months infants, reports indicate irregular use of iron supplementation in 75.5% and 73.3% in urban and rural regions, respectively. Recent investigations show that daily usage of daily iron supplementation for iron deficiency anemia is the same as weekly and twice weekly, but there is not any report on prophylaxis of iron deficiency anemia, so this is necessary to be investigated. Method & Material: In this randomized clinical trial study, 3 groups and each with 50 healthy 9-21 months infants with hemoglobin (Hb) less than 10.5 (g/dl) were selected. Sampling method was simple random sampling and iron supplementation administered daily, weekly and twice weekly in the 3 groups, respectively during a 3-months period. At the end of the research Hb was measured and information of each infant was recorded, then the average changes of Hb by using ANOVA and Chi-square statistical methods were compared. Results: The mean changes of Hb in 3 groups were 0.439, 0.225 and 0.063 (g/dl) respectively and there was not any difference between them. No case of anemia was observed at the end of intervention. The percentage of complications of iron supplementation was 11.1%, 10.5% and 5.5% in 3 groups respectively and there was no significant difference between them. Conclusion: Daily, weekly and twice a week administration of iron supplementation in infants has the same effect on mean changes of Hb anemia and complications.

Introduction: Epilepsy is one of the most prominent problems in pediatrics. Statistics show that 5 to 8 persons out of 1000 suffer from seizure disorders, and about 300.000 children in Iran have epilepsy, 40% of whom have partial seizure. This investigation was conducted to study the effectiveness and side effects of primidone, as the standard first line treatment of partial seizure and to compare it with carbamazepine. Method and Material: In this clinical trial study, 30 patients (<18 years old) including 20 boys and 10 girls, with newly diagnosed and previously untreated partial epileptic seizure from Bandar Abbas childrens hospital were enrolled. Subjects were randomly divided into two equal groups. Carbamazepine 15-25 mg/kg/day and primidone 10-25 mg/kg/day were administered to each of the patients during a 6- months period. Data analysis was performed using paired t-test and p<0.05 was considered as significant. Results: Mean seizure frequency in carbamazepine group was reduced from 2.5 times to 0.3 during the study period. In the primidone group, this figure reduced from 2 times to 0.07 times. The differences were statistically significant (p<0.05). The mean time of seizure in carbamazepine group was reduced from 5 minutes to 1.6 minutes. In primidone group, the mean time of seizure was reduced from 4.1 minutes to 0.37 minute. These differences were also significant (p<0.05). Discussion: Primidone and carbamazepine show similar efficacy against partial seizures in newly diagnosed epilepsy in children. Primidone, however, had better effect on EEG outcome. In conclusion, we suggest that after some more extensive studies, primidone can be used as the first choice of therapy for pediatric partial seizure.

Introduction: Opium dependence is one of important health problems in our country. Several researches showed many of patients with opium dependence have psychiatric disorders. The aim of this study was evaluation of psychiatric disorders in opium dependent patients and comparing psychiatric disorders between opium and heroin dependent patients. Method & Material: In this descriptive study, 192 male opium dependent patients who were admitted in dual-diagnosis ward of Beheshti hospital, Kerman, Iran for detoxification, were enrolled randomly. After evaluation of their demographic data, they were assessed by means of SCL-90-R standard test. Analysis of variance and chi-square tests were used for statistical analysis and P<0.05 was considered as significant. Results: The mean± SD of age of subjects was 33.92±7/67 years. All scales of SCL-90-R were evaluated as borderline or sick. Scores of obsession and compulsion, anxiety, phobia, psychosis, PST and GSI were significantly higher in patients with heroin dependence than patients with opium dependence. Conclusion: It is recommended that all of patients with opium dependence should be evaluated for comorbid psychiatric disorders, that may improve outcome of their dependence treatment. Heroin dependent patients have more psychopathology than opium dependent patients and need more attention.

Introduction: To improve educational quality and to achieve efficient clinical education, evaluation of existing condition is essencial. So, by detecting weak and strength points of education system the necessary decision can be made to remove the shortcomings. One of the most important tools to asses the educational condition is students opinion, so the residents opinion about clinical teaching in different educational groups was evaluated. Method & Material: In this descriptive study a self administered questionnaire consisting of 15 questions in different categories was used to gather the data. The validity and reliability of the questionnaire was detected by using usual methods. The questionnaires distributed among the residents of eleven educational groups and the results were presented by using descriptive methods. Educational Development Center, Kerman university of Medical Sciences. Results: The findings showed that the quality of practical educational skill was desirable. While the teaching method in other categories was in medium level. All of the surveyed categories showed a significant correlation (p<0.05). There was no significant difference between the residents opinion according to sex. Conclusion: Most of the residents believed that the teaching method was not appropriate. The medical faculty members begin their work immediately after getting their degree, while they are not familiar with the teaching, evaluation method and curriculum planning. The medical teaching method workshop can remove this problem.

Introduction: Gastrointestinal cancers are known as the most fatal cancers of human being, which are mostly related to nutritional factors. This study was designed to analysis the serum level of zinc in patients who suffer from adenocarcinoma of stomach and squamous cell carcinoma (S.C.S) of esophagus. Method & Material: In this case – control study, serum levels of zinc, albumin serum, globulin, total protein and cholesterol of 24 patients with adenocarcinoma and 42 patients with squamous cell carcinoma, as cases were compared with those of 33 healthy persons as controls. 10 ml of blood was taken and serum was analyzed. Serum zinc was measured by atomic absorption, Albumin with biuret method, total protein with refrectometer and cholesterol with hydrous method. T-test and Pearson Correlation coefficient were used for data analysis. Results: Results show that, there were no significant differences between serum levels in stomach cancer patients and esophagus cancer patients. However, a significant difference was shown in the serum levels of control group with those of cases (P<0.001). Mean serum levels of zinc in the adenocarcinoma patients was significantly lower than that of control group (P<0.001). Moreover, the mean serum globulin in cases was significantly less than mean globulin serum in Control group (P<0.01). Conclusion: This study showed that zinc serum, serum globulin and total protein levels for those who suffer from gastrointestinal cancers are significantly less than those from healthy subjects.

Introduction: It has been reported that increased oxidative stress in diabetes mellitus is associated with disorder of wound healing. On the other hand, vitamin C is an Antioxidant. The present study has investigated the effect of vitamin C supplementation on wound healing in non-diabetic and chronic diabetic rats. Method and material: This experimental study was performed on 80 male rats. Diabetes was induced on 4 groups by subcutaneous injection of streptozotocin (50 mg/kg). All rats were divided into 8 groups, 10 in each group. Group (I), was induced, and received vitamin C deficient diet. Group (II), diabetic prophylaxis, received 250 mg/lit vitamin C through their drinking water, one month before inducing diabetes. Group (III), diabetic treatment, received ascorbic acid (250 mg/lit) one month after induction of diabetes. Group (IV), combination diabetics, received vitamin C 30 days before diabetes induction until 60 days after diabetes induction. Non-diabetes groups (V-VIII) were treated like groups I-IV. Animals were made wounded by a circular 3 cm2 full thickness incision on back, 8 weeks after diabetic induction. Mean surface area, percentage of wound healing and time required for healing in different postoperative days were determined. Data analysis was done using analysis of variance and t-test and p<0.05 was considered as significant. Results: The results showed that, mean of wound surface area in non - diabetic rats was less than diabetic rats, and in 7th till 15th days, the difference was significant (P<0.001). Percentage of wound healing in healthy rats was higher than diabetic rats in all postoperative days. Furthermore, Percentage of wound healing in group (V) was more than group (I) and also, in group (I) it was more than that in groups (III) and (IV) for all postoperative days. Time required for wound healing in diabetic rats was III>IV>II>I and in non - diabetic rats was V> VII> VIII> VI. Discussion: This data suggest that, after induction of diabetes, vitamin C supplementation (250mg/lit) in chronic diabetic and in combination groups, impaired wound healing, while in non-diabetic rats, wound healing properly occurred.