In order to study the response of potato growth indices in the seed production and commercial crop plant densities to weed infestation period an experiment was conducted in Agricultural faculty of Bu-Ali Sina University in 2006. This experiment was a factorial experiment based on a randomized complete block design with three replications. Experimental treatments were potato plant density at two levels, 5.33 (optimum plant density of commercial fields) and 6.66 (optimum plant density of seed production fields) plant m-2 and weed infestation periods at seven levels, in which at the five levels, weeds were allowed to grow for 10, 20, 30, 40 and 50 days after crop emergence and then weeds were removed manually until harvest, In addition two control treatments (full- season weeded and full season infested) were taken. Each plot consisted of four rows (eight meter per rows) with a row spacing of 75 cm. In order to calculate the growth indices of crop sampling started from 10 days after crop emergence, and repeated in 10 days interval, for 11 times. The results showed that until 40 days after crop emergence, total dry matter accumulation was not affected by weed infestation period and about 90 days after crop emergence weed infestation had maximum effect of total dry matter. In the low plant density, the effect of weed infestation period on leaf area index, crop growth rate and tuber growth rate was more than those of high plant density. So that full- season weed competition led to a 44.4%, 36.5%, 42.3% and 40.0% reduction in above mentioned potato growth indices (at their maximum amount), respectively, in compared to weed- free treatment, at the low plant density. However, the reduction in the high plant density was 40.0%, 34.8%, 39.7% and 35.1 %, respectively. The effect of weed infestation on tuber yield in commercial plant density was more than those of seed production plant density.