Bachground: Obsessive-Compulsive Disorder-Due to symptoms can lead to problems in the interpersonal relationships of the affected individuals, which can aggravate or relapse the disease. Therfore, Functional Analytic with emphasis on intimacy and interpersonsl problems, can improve symptoms and prevent recurrence of the disease. Aim: Therefore, The purpose of this study was the efficacy of functional analytic psychotherapy (FAP) on Improving Depression and communication skill Obsessive-Compulsive Disorder. Method: The research method was quasi-experimental with pre-and-post design with control group. Therefore, 24 subjects were selected via accessible sampling from the clientele and divided into two groups. The tools used in this research were: Beck Depression Inventory (BDI, 1996) and communication skill Questionnaire(CSQ, 1983). Results: the results of covariance analysis indicated that the effect of experimental group had a significant effect on depression and communication skills (sig 0. 01). Conclusions: this suggests that Functional Analytic Psychotherapy could reduce the depression and in communication skills in patient with Obsessive-Compulsive Disorder.