This study was aimed to investigate the association of resilience with indices of vulnerability including psychological distress, depression, and anxiety; and mental health in a sample of the University of Tehran students. Two hundred and fourteen students (97 boys, 114 girls) were included in this study. All participants were asked to complete Connor- Davidson Resilience Scale (CD-RISC), Mental Health Inventory (MHI), Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI), and General Health Questionnaire (GHQ). The results revealed that resilience was positively associated with psychological well-being and negatively associated with psychological distress, depression and anxiety. Psychological health and vulnerability indices are influenced by different levels of resilience through self-esteem, personal competence and tenacity, tolerance of negative affect, control, and spirituality.