Gelatin/Polycaprolactone and Polyvinyl Alcohol/Chitosan Hybrid Nanofibers: Determining Factors on Their Morphology

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Ranjbar Mohammadi Marziyeh; Tajdar Farideh

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Journal Paper

Paper Information

Journal: IRANIAN JOURNAL OF POLYMER SCIENCE AND TECHNOLOGY Year:2022 | Volume:35 | Issue:3 Page(s): 203-216

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Information Journal Paper

Title

Gelatin/Polycaprolactone and Polyvinyl Alcohol/Chitosan Hybrid Nanofibers: Determining Factors on Their Morphology

Author(s)

Ranjbar Mohammadi Marziyeh | Tajdar Farideh | Issue Writer Certificate

Keywords

hybrid nanofibers

taguchi

chitosan

gelatin

polycaprolactone

Abstract

Hypothesis: Nowadays, nanotechnology has an important role in the medical industry. Electrospun nanofibers with interconnected structure, high surface-tovolume ratio and good porosity are used in various medical fields. Nanofibers morphology is very effective in their mechanical, thermal, physical and biological properties. The aim of this study is to produce structures with smooth surface and minimized diameter. Methods: Production assessments are made on hybrid nanofibrous structures using combinations of poly(vinyl alcohol)/chitosan (PVA/CS), and gelatin/polycaprolactone (Gel/PCL). The process is done through the electrospinning process of two nozzles facing each other. For this purpose, Gel/PCL has been injected from a nozzle and CS/PVA from another nozzle and the produced nanofibers are collected on a rotating collector. By a Taguchi test design the effect of variable parameters (PVA/CS ratios of 90: 10, 80: 20, 70: 30,gel/PCL ratios of 80: 20, 50: 50, 20: 80,and CS/PVA feed rates of 1, 1. 5, 2 mL/h) on morphological properties of the produced scaffold is evaluated. Findings: According to the results, nanofibers with the blend ratios of 75: 25 and 80: 20 for CS/PVA and gel/PCL, respectively, and flow rate of 1 mL/h for PVA/CS showed an average diameter of about 130 nm and a suitable morphology. A hybrid scaffold made of gel/PCL-PVA/CS can be considered as a very suitable and practical biomaterial in the field of diabetic wound healing, because the presence of gel and CS as natural polymers with excellent biological properties and PCL with high elastic property provide good conditions for imitating natural skin behavior.

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APA: Copy

Ranjbar Mohammadi, Marziyeh, & Tajdar, Farideh. (2022). Gelatin/Polycaprolactone and Polyvinyl Alcohol/Chitosan Hybrid Nanofibers: Determining Factors on Their Morphology. IRANIAN JOURNAL OF POLYMER SCIENCE AND TECHNOLOGY (PERSIAN), 35(3 ), 203-216. SID. https://sid.ir/paper/1038341/en

Vancouver: Copy

Ranjbar Mohammadi Marziyeh, Tajdar Farideh. Gelatin/Polycaprolactone and Polyvinyl Alcohol/Chitosan Hybrid Nanofibers: Determining Factors on Their Morphology. IRANIAN JOURNAL OF POLYMER SCIENCE AND TECHNOLOGY (PERSIAN)[Internet]. 2022;35(3 ):203-216. Available from: https://sid.ir/paper/1038341/en

IEEE: Copy

Marziyeh Ranjbar Mohammadi, and Farideh Tajdar, “Gelatin/Polycaprolactone and Polyvinyl Alcohol/Chitosan Hybrid Nanofibers: Determining Factors on Their Morphology,” IRANIAN JOURNAL OF POLYMER SCIENCE AND TECHNOLOGY (PERSIAN), vol. 35, no. 3 , pp. 203–216, 2022, [Online]. Available: https://sid.ir/paper/1038341/en

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