Evaluation of LncRNA SNHG15 Expression Changes in the Tissues of Glioblastoma Multiforme Patients Using Real-Time PCR

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Shakeri Yekta Sahar; Moslemi Elham; Sari Soyar; Rouhollah Fatemeh; Kheiri Hamidreza

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ISSN: 2588-4824

Journal Paper

Paper Information

Journal: JOURNAL OF ANIMAL BIOLOGY Year:2022 | Volume:15 | Issue:4 Page(s): 225-235

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Title

Evaluation of LncRNA SNHG15 Expression Changes in the Tissues of Glioblastoma Multiforme Patients Using Real-Time PCR

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Keywords

SNHG15Q4

Glioblastoma MultiformeQ4

Real-Time PCRQ4

LncRNAQ4

Gene ExpressionQ4

Abstract

Glioblastoma is an aggressive malignant tumor of the brain and spinal cord. Several lines of evidence indicate an important oncogenic role of highly non-coding RNA (LncRNA) molecules in a variety of cancers including glioma, however, the tumorigenic function of lens in glioma remains largely unclear. Increasing evidence has shown that LncRNAs, including LncRNA SNHG15, play an important role in the pathophysiology of human diseases, especially in the pathogenesis and progression of cancers. In this study, 25 paraffin tissue blocks of patients with Glioblastoma Multiforme and tumor margin tissue were collected and RNA extracted. Synthesis of cDNA and analysis of SNHG15 expression was done by Real-Time PCR technique. ROC curve was drawn to check the biomarker value and statistical analysis was done by GraphPad Prism v. 8. 0. 1. An increase in the expression of SNHG15 was recorded in the tissue samples of patients compared to the tissue of the tumor margin (p < 0. 0001). There was a significant relationship in the expression of this gene in patients aged more than 50 years and less than 50 years (p = 0. 6573), Frontal, Temporal, Parietal, Occipital, and Other locations (P value = 0. 9802), survival in more than 12 months and less than 12 months (p = 0. 5007) was not observed, only in male and female sex (p = 0. 0001) was registered. The expression of LncRNA SNHG15 was recorded in the tumor tissue of patients with Glioblastoma Multiforme more than in the peripheral tumor tissue. By examining the ROC curve, it is possible that LncRNA SNHG15 can be proposed as a biomarker, but it needs more studies.

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