Synthesis and Antidiabetic Assessment of New Coumarin-Disubstituted Benzene Conjugates: An In Silico–In Virto Study

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Jasim Sara Firas; Mustafa Yasser Fakri

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ISSN: 2588-4824

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Journal: Journal of Medicinal and Chemical Sciences Year:621 | Volume: | Issue: Page(s): 887-899

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Title

Synthesis and Antidiabetic Assessment of New Coumarin-Disubstituted Benzene Conjugates: An In Silico–In Virto Study

Author(s)

Jasim Sara Firas | Mustafa Yasser Fakri | Issue Writer Certificate

Keywords

Coumarin-disubstituted benzene conjugatesQ4

AntidiabeticQ4

AntioxidativeQ4

In-silicoQ4

Abstract

Even with the significant advancements in medical and therapeutical fields, finding efficient anti-diabetic and anti-oxidative entities is of high significance in the recent era. New Coumarin-disubstituted benzene conjugates were prepared to evaluate their Antidiabetic and Antioxidative effects. The prepared conjugates (MT0-MT7) were characterized utilizing various analytical techniques, including FTIR, UV–Vis, 1H-NMR, and 13C-NMR. Also, the drug-likeness properties of conjugates were assessed In-silico. The Antidiabetic effect of the prepared conjugates was estimated in-vitro based on their inhibitory impact on porcine α-amylase and yeast α-glucosidase enzymes; whereas their Antioxidative effect was appraised in-vitro based on their snaring impact on hydroxide and DPPH radicals. The findings of evaluating these effects demonstrated that the MT2 and MT3 conjugates had a prominent Antidiabetic effect related to the standard. In addition, the MT0 conjugate showed a distinct Antioxidative effect comparable to that of the standard. Thus, MT2, MT3, and MT0 conjugates could be used as scaffolds to develop a new class of Antidiabetic and Antioxidative entities. Moreover, the In-silico analysis revealed that the majority of the prepared conjugates had convenient drug-likeness properties for the oral drug-delivery system.

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