Green and Efficient Synthesis of Baclofen

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Fernandes Pearl Rhea; Madnala Ashwini; Donde Nisha; Pawar Amit; Sonawale Maryappa

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Journal Paper

Paper Information

Journal: Advanced Journal of Chemistry, Section B: Natural Products and Medical Chemistry Year:621 | Volume: | Issue: Page(s): 158-163

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Title

Green and Efficient Synthesis of Baclofen

Author(s)

Keywords

GABA agonistQ4

4-ChlorobenzaldehydeQ4

CyanohydrinQ4

OxidizingagentQ4

PyridiniumQ4

Wittig type reaction.Hydrolysis reductionQ4

Abstract

Baclofen is a Gamma Amino Butyric acid (GABA) agonist to relax skeletal muscles. It is especially effective in treating muscular spasticity. In this research, we now describe the synthesis of Baclofen using a new approach which begins with 4- chlorobenzaldehyde. We have carried all reactions by the green method. It gives the better yield. The identity of this product was confirmed by spectral analysis and compared with the standard Baclofen. New and eco-friendly approach was developed for the synthesis

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