Synthesis of methoxy amido xanthate ligand and optimization of 99mTc labeling conditions as SPECT imaging agent

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Arab Halvaiee Bagheri Z.; Aghamiri S.M.R.; Sattarzadeh Khameneh E.; Kakaei S.; Yousefnia H.

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Journal Paper

Paper Information

Journal: Journal of Nuclear Science, Engineering and Technology Year:2023 | Volume:44 | Issue:2 Page(s): 13-21

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Information Journal Paper

Title

Synthesis of methoxy amido xanthate ligand and optimization of 99mTc labeling conditions as SPECT imaging agent

Author(s)

Keywords

Labeling

Chelator

Methoxy Amido Xanthate (MAX)

SPECT

Technetium-99m

Abstract

In the present study, the aim is to synthesize and introduce the combination of Methoxy Amido Xanthate (MAX) and then label it with 99mTc radionuclide as a novel diagnostic agent for single-photon computed tomography (SPECT) imaging. A Chelator-designed ligand was synthesized from a blend of chloroacetamide and xanthate in certain proportions. After that MAX ligand Labeling process was performed by directly milking 99mTc from the generator (99Mo / 99mTc). Thus, tin chloride was employed as a reducing agent, and the effect of parameters such as additives like ascorbic acid, changing the concentration of the cheating agent, and pH were evaluated to optimize the Labeling conditions. The product was then identified by infrared SPECTroscopy (FTIR) and magnetic resonance imaging (NMR). Labeling of the complex at laboratory temperature was determined to be 93%. The new 99mTc-MAX radiopharmaceutical with a radionuclide and radiochemical purity of over 90% can be used as an encouraging diagnostic agent in clinics and preclinical studies, which will be addressed in future studies.

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