Introduction of radio nanocomposite [89Zr]Zr-CdTe QDs as a PET imaging agent

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Feizi Sh.; Fazaeli S.Y.; Ashtari P.; Zare H.; Bolori Novin F.

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Journal Paper

Paper Information

Journal: Journal of Nuclear Science, Engineering and Technology Year:2024 | Volume:45 | Issue:2 Page(s): 100-104

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Title

Introduction of radio nanocomposite [89Zr]Zr-CdTe QDs as a PET imaging agent

Author(s)

Keywords

Quantum dots

Zirconium-89

Labeling

PET imaging

Abstract

The present study focuses on the performance and biodistribution of cadmium telluride Quantum dots labeled with Zirconium-89. Synthesis and characterization of cadmium telluride Quantum dots, radiolabeling and quality control, and then animal studies including investigating biodistribution, tumor accumulation, how to clear up the radiopharmaceutical from the body and positron emission tomography images have been studied. Cadmium telluride Quantum dots with 3 nm dimensions were chemically synthesized. The Labeling reaction was performed starting with zirconium chloride and CdTe QDs. In order to evaluate the in vivo behavior of [89Zr]Zr-CdTe QDs and to compare it with Zirconium-89 ([89Zr]Zr-Chloride), PET imaging experiments were designed and performed. Immediately after each imaging, the mice were dissected and the biodistribution of the radiopharmaceutical to different organs was evaluated. The results indicated the rapid and targeted accumulation of these radionanoparticles in the tumor. Due to the superior properties of the Zirconium-89 radioisotope and appropriate biodistribution, these labeled nanoparticles were introduced as potential nuclear imaging agents.

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