THE USE OF SELF-ASSEMBLY STRUCTURES IN SPIRULINA ISC6 FOR DRUG DELIVERY

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HAJRAFI ALI; DEZFULIAN MEHROUZ; SOLTANI NEDA; HARZANDI NASER; YAGHOUB ZADEH SAREH; RAZAVI DAVOODI NEDA

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Journal: Environmental Sciences Year:2012 | Volume:9 | Issue:SPECIAL ISSUE Page(s): 9-16

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Title

THE USE OF SELF-ASSEMBLY STRUCTURES IN SPIRULINA ISC6 FOR DRUG DELIVERY

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Keywords

SPIRULINA ISC6Q2

S-LAYERQ2

L-ASPARAGINASEQ2

CANCER CELL LINEQ2

Abstract

The S-LAYER is the surface cell wall layer in cyanobacteria. S-LAYERs have a 5–10 nm thickness and identical, regularly arranged pores with diameters of 2–8 nm. The self-assembly process can occur in the air-water interface. Drug targeting is the selective delivery of drugs to particular tissues and cells and it can increase the efficiency of medical treatment, reduce the required dose and decrease the side effects of a drug. The mechanisms of attaching drugs to drug targeting materials vary according to the physicochemical properties of these materials. In this study, the S-LAYER of SPIRULINA ISC6 cyanobacteria was used to deliver the anti-blood cancer drug L-ASPARAGINASE to CANCER CELL LINEs. In this study the use of nano particles of the SPIRULINA ISC6 S-LAYER for the delivery of L-ASPARAGINASE to CANCER CELL LINEs was investigated. SPIRULINA ISC6 was cultured in zarrouk media and the S-LAYER was extracted from the outer membrane of cyanobacteria using the standard method. Quantification and qualification of the extracted S-LAYER was done and it was sterilized by filtration. Different concentrations of S-LAYER and L-ASPARAGINASE were tested on cancer cells. The cell mortality was compared with that of untreated cells, S-LAYER alone and L-ASPARAGINASE treated cells alone. Results showed that cancer cells treated with S-LAYER and L-ASPARAGINASE decreased better than cancer cells treated with other compounds.

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APA: Copy

HAJRAFI, ALI, DEZFULIAN, MEHROUZ, SOLTANI, NEDA, HARZANDI, NASER, YAGHOUB ZADEH, SAREH, & RAZAVI DAVOODI, NEDA. (2012). THE USE OF SELF-ASSEMBLY STRUCTURES IN SPIRULINA ISC6 FOR DRUG DELIVERY. ENVIRONMENTAL SCIENCES, 9(SPECIAL ISSUE), 9-16. SID. https://sid.ir/paper/117296/en

Vancouver: Copy

HAJRAFI ALI, DEZFULIAN MEHROUZ, SOLTANI NEDA, HARZANDI NASER, YAGHOUB ZADEH SAREH, RAZAVI DAVOODI NEDA. THE USE OF SELF-ASSEMBLY STRUCTURES IN SPIRULINA ISC6 FOR DRUG DELIVERY. ENVIRONMENTAL SCIENCES[Internet]. 2012;9(SPECIAL ISSUE):9-16. Available from: https://sid.ir/paper/117296/en

IEEE: Copy

ALI HAJRAFI, MEHROUZ DEZFULIAN, NEDA SOLTANI, NASER HARZANDI, SAREH YAGHOUB ZADEH, and NEDA RAZAVI DAVOODI, “THE USE OF SELF-ASSEMBLY STRUCTURES IN SPIRULINA ISC6 FOR DRUG DELIVERY,” ENVIRONMENTAL SCIENCES, vol. 9, no. SPECIAL ISSUE, pp. 9–16, 2012, [Online]. Available: https://sid.ir/paper/117296/en

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