A CALORIMETRIC STUDY ON THE INTERACTION OF ZINC ION WITH HUMAN GROWTH HORMONE

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TAZIKEH E.; SABOURY A.A.; REZAEI BEHBEHANI G.; MOOSAVI MOVAHEDI A.A.; MONAJJEMI M.

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Journal: IRANIAN JOURNAL OF SCIENCE AND TECHNOLOGY TRANSACTION A- SCIENCE Year:2009 | Volume:33 | Issue:A4 Page(s): 317-327

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Title

A CALORIMETRIC STUDY ON THE INTERACTION OF ZINC ION WITH HUMAN GROWTH HORMONE

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Keywords

HUMAN GROWTH HORMONE (HGH)Q3

ISOTHERMAL TITRATION CALORIMETRY (ITC)Q3

SOLVATION MODELQ3

ZINC IONQ3

METAL BINDINGQ3

INTERACTIONQ3

LIGAND BINDINGQ3

BIOTHERMODYNAMICSQ3

ENTHALPY OF BINDINGQ3

INTRINSIC EQUILIBRIUM CONSTANTQ3

Abstract

A thermodynamic study on the INTERACTION between ZINC ION (Zn2+) and human growth hormone (hGH) was studied at two temperatures of 27oC and 37oC in aqueous solution using an isothermal titration calorimetry. It was found that there is a set of three identical and non-interacting binding sites for Zn2+ ions. The intrinsic dissociation equilibrium constant and the molar ENTHALPY OF BINDING are 1.54 mM and-17.6 kJ mol-1 at 27oC and 1.93 mM and -17.1 kJ mol-1 at 37oC, respectively. To reproduce the binding parameters of metal ion-hormone INTERACTION over the whole range of Zn2+ concentrations a solvation theory was applied. The binding parameters deduced from the SOLVATION MODEL were attributed to the structural change of hGH and its biological activity due to the metal ion INTERACTION.

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APA: Copy

TAZIKEH, E., SABOURY, A.A., REZAEI BEHBEHANI, G., MOOSAVI MOVAHEDI, A.A., & MONAJJEMI, M.. (2009). A CALORIMETRIC STUDY ON THE INTERACTION OF ZINC ION WITH HUMAN GROWTH HORMONE. IRANIAN JOURNAL OF SCIENCE AND TECHNOLOGY TRANSACTION A- SCIENCE, 33(A4), 317-327. SID. https://sid.ir/paper/117995/en

Vancouver: Copy

TAZIKEH E., SABOURY A.A., REZAEI BEHBEHANI G., MOOSAVI MOVAHEDI A.A., MONAJJEMI M.. A CALORIMETRIC STUDY ON THE INTERACTION OF ZINC ION WITH HUMAN GROWTH HORMONE. IRANIAN JOURNAL OF SCIENCE AND TECHNOLOGY TRANSACTION A- SCIENCE[Internet]. 2009;33(A4):317-327. Available from: https://sid.ir/paper/117995/en

IEEE: Copy

E. TAZIKEH, A.A. SABOURY, G. REZAEI BEHBEHANI, A.A. MOOSAVI MOVAHEDI, and M. MONAJJEMI, “A CALORIMETRIC STUDY ON THE INTERACTION OF ZINC ION WITH HUMAN GROWTH HORMONE,” IRANIAN JOURNAL OF SCIENCE AND TECHNOLOGY TRANSACTION A- SCIENCE, vol. 33, no. A4, pp. 317–327, 2009, [Online]. Available: https://sid.ir/paper/117995/en

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