biocompatibility investigation of hydroxyapatite/chitosan nanocomposites doped by metal oxides

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Esmaeilzadeh Alireza; Haghbin lasht Neshani Saeede; Heshmatpour Felora

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Journal Paper

Paper Information

Journal: Nashrieh Shimi va Mohandesi Shimi Iran Year:2023 | Volume:42 | Issue:1 Page(s): 13-21

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Information Journal Paper

Title

biocompatibility investigation of hydroxyapatite/chitosan nanocomposites doped by metal oxides

Author(s)

Esmaeilzadeh Alireza | Haghbin lasht Neshani Saeede | Heshmatpour Felora | Issue Writer Certificate

Keywords

HydroxyapatiteQ4

Metal oxideQ4

BioactivityQ4

CytotoxicityQ4

Abstract

Nano Hydroxyapatite (nHA) composites have been widely used in bone regeneration due to their unique properties. In this paper, doped nHA composites with doping of MgO, ZnO, and CeO2 Metal oxides into nHA structure were successfully attained using precipitation method. Also, chitosan (CS) was added to the nHA composites to improve the biocompatibility. As the results showed, doping the Metal oxides into the nHA structure led to the change of the lattice parameters in nHA structure. Finally, Bioactivity of the composites was investigated by MTT assay by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide. MTT assay is shown that doped-nHA structure gives acceptable Cytotoxicity against the MG-63 cell.

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