CURCUMIN-LOADED CHITOSAN TRIPOLYPHOSPHATE NANOPARTICLES AS A SAFE, NATURAL AND EFFECTIVE ANTIBIOTIC INHIBITS THE INFECTION OF STAPHYLOCOCCUS AUREUS AND PSEUDOMONAS AERUGINOSA IN VIVO

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MOFAZZAL JAHROMI MIRZA ALI; AL MUSAWI SHARAFALDIN; PIRESTANI MAJID; FASIHI RAMANDI MAHDI; AHMADI KAZEM; RAJAYI HAJAR; MOHAMMAD HASSAN ZUHAIR; KAMALI MAHDI; MIRNEJAD REZA

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Journal: Iranian Journal of Biotechnology Year:2014 | Volume:12 | Issue:3 (47) Page(s): 1-8

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Title

CURCUMIN-LOADED CHITOSAN TRIPOLYPHOSPHATE NANOPARTICLES AS A SAFE, NATURAL AND EFFECTIVE ANTIBIOTIC INHIBITS THE INFECTION OF STAPHYLOCOCCUS AUREUS AND PSEUDOMONAS AERUGINOSA IN VIVO

Author(s)

Keywords

CHITOSAN-TPPQ1

CURCUMINQ1

NANOPARTICLESQ2

PSEUDOMONAS AERUGINOSAQ2

STAPHYLOCOCCUS AUREUSQ2

Abstract

Background: CURCUMIN as a yellow natural compound extracted from turmeric root is known it as an antibacterial agent. One of the NANOPARTICLES ability is to decrease the defects of usual drug delivery systems. Chitosan is a low toxic, biodegradable, biocompatible and safe polymer which is used in production of NANOPARTICLES. NANOPARTICLES like chitosan-tripolyphosphate (TPP) are able to increase antibacterial properties of CURCUMIN.Materials and Methods: CURCUMIN-loaded CHITOSAN-TPP NANOPARTICLES containing chitosan, CURCUMIN and TPP salt were synthesized by ionotropic gelation methods. First, the skin of anesthetized mice was inoculated with STAPHYLOCOCCUS AUREUS and PSEUDOMONAS AERUGINOSA suspension. Then the infected mice were treated with CURCUMIN-loaded CHITOSAN-TPP NANOPARTICLES for 3 days. Following that, antibacterial characteristics of the mice treated with CURCUMIN-loaded chitosan- TPP NANOPARTICLES were evaluated by bacterial culture of these mice.Results: Our results showed the size of 160±10 nm and the charge of+7±2 mV in CURCUMIN-loaded CHITOSAN-TPP NANOPARTICLES. These NANOPARTICLES were also spiral shape. The encapsulation efficiency of CURCUMIN in CHITOSAN-TPP NANOPARTICLES was 75±2%. Bacterial culture showed that CURCUMIN-loaded CHITOSAN-TPP NANOPARTICLES inhibited STAPHYLOCOCCUS AUREUS and PSEUDOMONAS AERUGINOSA growth.Conclusions: Our study demonstrated that CURCUMIN-loaded CHITOSAN-TPP NANOPARTICLES can be utilized as a potent agent in treatment of STAPHYLOCOCCUS AUREUS and PSEUDOMONAS AERUGINOSA infections.

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APA: Copy

MOFAZZAL JAHROMI, MIRZA ALI, AL MUSAWI, SHARAFALDIN, PIRESTANI, MAJID, FASIHI RAMANDI, MAHDI, AHMADI, KAZEM, RAJAYI, HAJAR, MOHAMMAD HASSAN, ZUHAIR, KAMALI, MAHDI, & MIRNEJAD, REZA. (2014). CURCUMIN-LOADED CHITOSAN TRIPOLYPHOSPHATE NANOPARTICLES AS A SAFE, NATURAL AND EFFECTIVE ANTIBIOTIC INHIBITS THE INFECTION OF STAPHYLOCOCCUS AUREUS AND PSEUDOMONAS AERUGINOSA IN VIVO. IRANIAN JOURNAL OF BIOTECHNOLOGY, 12(3 (47)), 1-8. SID. https://sid.ir/paper/139219/en

Vancouver: Copy

MOFAZZAL JAHROMI MIRZA ALI, AL MUSAWI SHARAFALDIN, PIRESTANI MAJID, FASIHI RAMANDI MAHDI, AHMADI KAZEM, RAJAYI HAJAR, MOHAMMAD HASSAN ZUHAIR, KAMALI MAHDI, MIRNEJAD REZA. CURCUMIN-LOADED CHITOSAN TRIPOLYPHOSPHATE NANOPARTICLES AS A SAFE, NATURAL AND EFFECTIVE ANTIBIOTIC INHIBITS THE INFECTION OF STAPHYLOCOCCUS AUREUS AND PSEUDOMONAS AERUGINOSA IN VIVO. IRANIAN JOURNAL OF BIOTECHNOLOGY[Internet]. 2014;12(3 (47)):1-8. Available from: https://sid.ir/paper/139219/en

IEEE: Copy

MIRZA ALI MOFAZZAL JAHROMI, SHARAFALDIN AL MUSAWI, MAJID PIRESTANI, MAHDI FASIHI RAMANDI, KAZEM AHMADI, HAJAR RAJAYI, ZUHAIR MOHAMMAD HASSAN, MAHDI KAMALI, and REZA MIRNEJAD, “CURCUMIN-LOADED CHITOSAN TRIPOLYPHOSPHATE NANOPARTICLES AS A SAFE, NATURAL AND EFFECTIVE ANTIBIOTIC INHIBITS THE INFECTION OF STAPHYLOCOCCUS AUREUS AND PSEUDOMONAS AERUGINOSA IN VIVO,” IRANIAN JOURNAL OF BIOTECHNOLOGY, vol. 12, no. 3 (47), pp. 1–8, 2014, [Online]. Available: https://sid.ir/paper/139219/en

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