POLYMORPHISM OF PRION PROTEIN GENE (PRNP) IN IRANIAN HOLSTEIN AND TWO LOCAL CATTLE POPULATIONS (GOLPAYEGANI AND SISTANI) OF IRAN

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MAGHSOODI SABER MOHAMMAD; MIRAEI ASHTIANI SEYED REZA; BANABAZI MOHAMMAD HOSSEIN; MEHRABANI YEGANEH HASSAN

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Journal: Iranian Journal of Biotechnology Year:2011 | Volume:9 | Issue:2 Page(s): 115-119

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Title

POLYMORPHISM OF PRION PROTEIN GENE (PRNP) IN IRANIAN HOLSTEIN AND TWO LOCAL CATTLE POPULATIONS (GOLPAYEGANI AND SISTANI) OF IRAN

Author(s)

MAGHSOODI SABER MOHAMMAD | MIRAEI ASHTIANI SEYED REZA | BANABAZI MOHAMMAD HOSSEIN | MEHRABANI YEGANEH HASSAN | Issue Writer Certificate

Keywords

BOVINE SPONGIFORM ENCEPHALOPATHY (BSE)Q2

PRNP GENEQ2

IRANIAN HOLSTEINQ3

GOLPAYEGANI CATTLEQ2

SISTANI CATTLEQ3

GENETIC SUSCEPTIBILITYQ2

Abstract

Bovine spongiform encephalopathy (BSE) is a fatal infectious neurodegenerative disease in cattle, characterized by the accumulation of an abnormal, proteaseresistant prion protein (PrPSc) in the brain. BSE is similar to scrapie in sheep and goats and Creuzfeldt- Jakob disease in humans. Susceptibility in cattle has been shown to be under the influence of two polymorphic locations, which are a 23 bp in/del polymorphism and a 12 bp indel within intron 1 of the prion protein gene (PRNP). DNA was extracted from blood samples of three Iranian cattle populations including Sistani (Bos indicus) (n=60), Golpayegani (Bos indicus) (n=62) and IRANIAN HOLSTEIN (Bos taurus) (n=50), In order to identify the putative polymorphisms of the PRNP GENE of those breeds. Allele, genotype and haplotype frequencies of the polymorphisms were determined for the three populations. Susceptibility analysis was considered as per literature, upon which, it was suggested that the two Bos indicus native populations are more resistant to BSE than the IRANIAN HOLSTEIN (Bos taurus), due to higher gene frequency for insertion allele of the intron 1 of the PRNP GENE polymorphism.

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APA: Copy

MAGHSOODI, SABER MOHAMMAD, MIRAEI ASHTIANI, SEYED REZA, BANABAZI, MOHAMMAD HOSSEIN, & MEHRABANI YEGANEH, HASSAN. (2011). POLYMORPHISM OF PRION PROTEIN GENE (PRNP) IN IRANIAN HOLSTEIN AND TWO LOCAL CATTLE POPULATIONS (GOLPAYEGANI AND SISTANI) OF IRAN. IRANIAN JOURNAL OF BIOTECHNOLOGY, 9(2), 115-119. SID. https://sid.ir/paper/139244/en

Vancouver: Copy

MAGHSOODI SABER MOHAMMAD, MIRAEI ASHTIANI SEYED REZA, BANABAZI MOHAMMAD HOSSEIN, MEHRABANI YEGANEH HASSAN. POLYMORPHISM OF PRION PROTEIN GENE (PRNP) IN IRANIAN HOLSTEIN AND TWO LOCAL CATTLE POPULATIONS (GOLPAYEGANI AND SISTANI) OF IRAN. IRANIAN JOURNAL OF BIOTECHNOLOGY[Internet]. 2011;9(2):115-119. Available from: https://sid.ir/paper/139244/en

IEEE: Copy

SABER MOHAMMAD MAGHSOODI, SEYED REZA MIRAEI ASHTIANI, MOHAMMAD HOSSEIN BANABAZI, and HASSAN MEHRABANI YEGANEH, “POLYMORPHISM OF PRION PROTEIN GENE (PRNP) IN IRANIAN HOLSTEIN AND TWO LOCAL CATTLE POPULATIONS (GOLPAYEGANI AND SISTANI) OF IRAN,” IRANIAN JOURNAL OF BIOTECHNOLOGY, vol. 9, no. 2, pp. 115–119, 2011, [Online]. Available: https://sid.ir/paper/139244/en

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