An analysis of epileptogenesis-related proteins involved in cAMP signaling

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

Dashtban Moghadam Elahe; Khodaverdian Shima; Dabirmanesh Bahareh; Mirnajafi Zadeh Javad; Fatholahi Yaghoub; Khajeh Khosro

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Journal of Molecular and Cellular Researches Year:2024 | Volume:37 | Issue:2 Page(s): 202-218

Download Full-Text

Persian Verion

View:

Download:

Cites:

Information Journal Paper

Title

An analysis of epileptogenesis-related proteins involved in cAMP signaling

Author(s)

Keywords

shotgun proteomics

epileptogenesis

electrical kindling

Hippocampus

Abstract

Epilepsy is a chronic neurological disorder that lacks an effective treatment, and most patients do not respond to existing medications. It is due to the lack of a molecular mechanism of epilepsy and the incomplete understanding of proteins that are involved that epilepsy is largely unknown. It is therefore important to identify and control the epileptic process so that relevant and effective drug treatments can be administered. This study used the electrical kindling method and the proteomics shotgun technique to analyze the proteomes of rats during epileptogenesis. From the analysis of system biology data, it was determined that the cAMP signaling pathway is involved in epilepsy, as well as changes in the expression of proteins that are upstream and downstream of this secondary messenger in the stages of electrical kindling was observed. There was a significant decrease in expression of somatostatin neuropeptide from upstream proteins and an increase in expression of phospholipase D2 and AMPA glutamate receptor type 2 from downstream proteins during epilepsy. Taking advantage of these data, we can consider a new method to identify the mechanism of epilepsy and introduce new drug targets by identifying changes in the expression of cAMP signaling pathway proteins and their roles in the epilepsy process.

Multimedia

No record.

Cites

No record.

References

No record.

Cite

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans