Production and quality control of the 132/135La theranostic pair for targeted radiotherapy

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Shirpoor A.; Haddadi A.; Zolghadri S.; Vosoughi S.; Rajabifar S.

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Journal Paper

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Journal: Journal of Nuclear Science, Engineering and Technology Year:2025 | Volume:46 | Issue:2 Page(s): 160-169

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Title

Production and quality control of the 132/135La theranostic pair for targeted radiotherapy

Author(s)

Keywords

Theranostic

132/135La

radiochemical separation

Labeling

DOTA Chelator

Abstract

Among promising radioisotopes, 132/135La stands out as a Theranostic pair, offering specific advantages for the preparation of a wide range of radiopharmaceuticals. In this study, the Theranostic pair 132/135La was produced through the interaction of natBa(p,x)13xLa, using theoretical calculations with the nuclear codes ALICE-91, TALYS-1.8, and SRIM-2013. The natural barium target was then irradiated in a 30 MeV cyclotron with 22.5 MeV protons and a current of 100 μAh. After the lanthanum was separated from the irradiated target, the solution's chemical purity, radiochemical purity, and radionuclide purity were examined using ICP-OES, RTLC, and gamma spectrometry, respectively. The study also investigated the effect of increasing the concentration of the chelator DOTA (1-100 nanomolar) on its Labeling with lanthanum. The results showed that the average total amount of metal ions in the final solution was less than 0.1 ppm, with radiochemical and radionuclide purities above 99% and 99.5%, respectively. The Labeling of the chelator DOTA with lanthanum demonstrated that even with the addition of 1 nmol of this chelator, a radiochemical purity higher than 93% was achieved. This study indicates that it is possible to produce lanthanum radionuclides with the required quality for the development of Theranostic radiopharmaceuticals.

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