CENTRAL EFFECT OF HISTAMINE ON ACETIC ACID-INDUCED VISCERAL NOCICEPTION IN RATS

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ZANBOURI A.; TAMADONFARD E.; MOJTAHEDIN A.

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Journal: Iranian Journal of Veterinary Medicine Year:2010 | Volume:4 | Issue:1 Page(s): 17-21

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Information Journal Paper

Title

CENTRAL EFFECT OF HISTAMINE ON ACETIC ACID-INDUCED VISCERAL NOCICEPTION IN RATS

Author(s)

ZANBOURI A. | TAMADONFARD E. | MOJTAHEDIN A. | Issue Writer Certificate

Keywords

BRAINQ3

HISTAMINEQ2

CHLORPHENIRAMINEQ3

RANITIDINEQ3

VISCERAL NOCICEPTIONQ3

RATSQ3

Abstract

In the present study, the effects of intracerebroventricular (ICV) injections of HISTAMINE, CHLORPHENIRAMINE (H)-receptor antagonist) and RANITIDINE (Hz-receptor antagonist) were investigated on VISCERAL NOCICEPTION induced by an intraperitoneal (IP) injection of acetic acid in RATS. The latency time to the beginning of the first abdominal wall contraction (the first writhe) was recorded and the number of writhes was counted for 1h after the IP injection of acetic acid (1 ml, 1%).All treatments (histamine: 2.5-80 mg, CHLORPHENIRAMINE and RANITIDINE: 5-80 mg) did not influence the latency time to the beginning of the first writhe significantly except for the 40 mg dose of HISTAMINE, which significantly increased the latency time (p<0.05). Doses of HISTAMINE of 10 and 40 mg and doses of CHLORPHENIRAMINE and RANITIDINE of 20 and 80 mg significantly decreased the number of writhes (p<0.05). Pretreatments with CHLORPHENIRAMINE or RANITIDINE at the dose of 80 mg significantly prevented HISTAMINE-induced (40 mg) antinociception (p<0.05). These results indicate that BRAIN HISTAMINE may mediate the perception of visceral antinociception through both centralH) andHzreceptors.

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APA: Copy

ZANBOURI, A., TAMADONFARD, E., & MOJTAHEDIN, A.. (2010). CENTRAL EFFECT OF HISTAMINE ON ACETIC ACID-INDUCED VISCERAL NOCICEPTION IN RATS. IRANIAN JOURNAL OF VETERINARY MEDICINE (INTERNATIONAL JOURNAL OF VETERINARY RESEARCH), 4(1), 17-21. SID. https://sid.ir/paper/157886/en

Vancouver: Copy

ZANBOURI A., TAMADONFARD E., MOJTAHEDIN A.. CENTRAL EFFECT OF HISTAMINE ON ACETIC ACID-INDUCED VISCERAL NOCICEPTION IN RATS. IRANIAN JOURNAL OF VETERINARY MEDICINE (INTERNATIONAL JOURNAL OF VETERINARY RESEARCH)[Internet]. 2010;4(1):17-21. Available from: https://sid.ir/paper/157886/en

IEEE: Copy

A. ZANBOURI, E. TAMADONFARD, and A. MOJTAHEDIN, “CENTRAL EFFECT OF HISTAMINE ON ACETIC ACID-INDUCED VISCERAL NOCICEPTION IN RATS,” IRANIAN JOURNAL OF VETERINARY MEDICINE (INTERNATIONAL JOURNAL OF VETERINARY RESEARCH), vol. 4, no. 1, pp. 17–21, 2010, [Online]. Available: https://sid.ir/paper/157886/en

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