THE EFFECT OF INTRAPERITONEAL INJECTION OF VITAMIN C ON THE PAIN AND EDEMA INDUCED BY FORMALIN AND HISTAMINE IN RATS

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TAMADONFARD E.; ERFANPARAST A.

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Journal: SCIENTIFIC-RESEARCH IRANIAN VETERINARY JOURNAL Year:2009 | Volume:4 | Issue:5 (22) Page(s): 15-24

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Title

THE EFFECT OF INTRAPERITONEAL INJECTION OF VITAMIN C ON THE PAIN AND EDEMA INDUCED BY FORMALIN AND HISTAMINE IN RATS

Author(s)

TAMADONFARD E. | ERFANPARAST A. | Issue Writer Certificate

Keywords

VITAMIN CQ2

PAINQ2

EDEMAQ3

FORMALINQ3

HISTAMINEQ2

RATQ2

Abstract

In the present study, the effect of VITAMIN C was evaluated on PAIN and EDEMA induced by FORMALIN and HISTAMINE in male Wistar RATs. Normal saline (control) and VITAMIN C were intraperitoneally injected prior to injection of HISTAMINE and FORMALIN. PAIN and EDEMA were induced by subcutaneous injection of 50 ml of FORMALIN and HISTAMINE at the same concentration of 1% into the hind paw. PAIN response including licking and biting of the injected paw was recorded at 5 min intervals for a total of 1h. For evaluation of EDEMA, the thickness of both injected and non-injected paws was measured using a fine caliper. The results showed that FORMALIN produced a biphasic (first phase: 0-5 and min phase: 15-35 min), but HISTAMINE induced a short-time (0-5 min) PAIN response. Both FORMALIN and HISTAMINE increased the paw thickness. VITAMIN C (5, 10 and 20 mg/kg, ip) significantly (p<0.05) decreased the second phase of FORMALIN-induced PAIN. The PAIN induced by HISTAMINE was significantly (p<0.05) decreased by VITAMIN C at the doses of 2.5-20 mg/kg. VITAMIN C at the doses of 10 and 20 mg/kg significantly (p<0.05) decreased the paw EDEMA induced by FORMALIN and HISTAMINE. It is concluded that FORMALIN induces more intense PAIN than HISTAMINE, whereas FORMALIN and HISTAMINE produce EDEMA with the same intensity. However, VITAMIN C has an ability to reduce the PAIN and EDEMA induced by FORMALIN and HISTAMINE.

Cites

EFFECT OF CHLORPHENIRAMINE ON PAIN RESPONSE INDUCED BY PLANTAR INJECTION OF FORMALIN AND HISTAMINE IN SCIATIC NERVE-LIGATED AND NON-LIGATED RATS

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APA: Copy

TAMADONFARD, E., & ERFANPARAST, A.. (2009). THE EFFECT OF INTRAPERITONEAL INJECTION OF VITAMIN C ON THE PAIN AND EDEMA INDUCED BY FORMALIN AND HISTAMINE IN RATS. SCIENTIFIC-RESEARCH IRANIAN VETERINARY JOURNAL, 4(5 (22)), 15-24. SID. https://sid.ir/paper/97437/en

Vancouver: Copy

TAMADONFARD E., ERFANPARAST A.. THE EFFECT OF INTRAPERITONEAL INJECTION OF VITAMIN C ON THE PAIN AND EDEMA INDUCED BY FORMALIN AND HISTAMINE IN RATS. SCIENTIFIC-RESEARCH IRANIAN VETERINARY JOURNAL[Internet]. 2009;4(5 (22)):15-24. Available from: https://sid.ir/paper/97437/en

IEEE: Copy

E. TAMADONFARD, and A. ERFANPARAST, “THE EFFECT OF INTRAPERITONEAL INJECTION OF VITAMIN C ON THE PAIN AND EDEMA INDUCED BY FORMALIN AND HISTAMINE IN RATS,” SCIENTIFIC-RESEARCH IRANIAN VETERINARY JOURNAL, vol. 4, no. 5 (22), pp. 15–24, 2009, [Online]. Available: https://sid.ir/paper/97437/en

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