EFFECT OF CHLORPHENIRAMINE ON PAIN RESPONSE INDUCED BY PLANTAR INJECTION OF FORMALIN AND HISTAMINE IN SCIATIC NERVE-LIGATED AND NON-LIGATED RATS

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TAMADDONFARD E.; KARAMI P.

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Journal: SCIENTIFIC-RESEARCH IRANIAN VETERINARY JOURNAL Year:2011 | Volume:7 | Issue:3 (32) Page(s): 13-22

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Title

EFFECT OF CHLORPHENIRAMINE ON PAIN RESPONSE INDUCED BY PLANTAR INJECTION OF FORMALIN AND HISTAMINE IN SCIATIC NERVE-LIGATED AND NON-LIGATED RATS

Author(s)

TAMADDONFARD E. | KARAMI P. | Issue Writer Certificate

Keywords

CHLORPHENIRAMINEQ2

FORMALINQ3

HISTAMINEQ2

SCIATIC NERVEQ3

PAINQ2

RATQ2

Abstract

Histamine, through its HI receptors, plays an important role in modulation of PAIN. In this study, the effect of CHLORPHENIRAMINE (an antagonist of HISTAMINE HI receptors) was investigated on PAIN response induced by sub-plantar injection of FORMALIN and HISTAMINE in sciatic ligated and non-ligated RATs. The ligation of SCIATIC NERVE was induced by tying four loose ligatures around the trunk of left SCIATIC NERVE. Thirteen days after surgery, after intraperitoneal injections of normal saline (control) and CHLORPHENIRAMINE (5 mg/kg) in ligated and non-ligated RATs, subcutaneous injections of 40 ml normal saline, FORMALIN (2.5%) and HISTAMINE (2.5%) into the plantar surface of left hind paw were performed. PAIN responses including lifting, licking and biting of the injected paw were scored. Control groups (intraperitoneal and sub-plantar injections of normal saline) produced negligible PAINresponses. In the non-ligated animals, FORMALIN produced a biphasic PAIN and HISTAMINE induced a short-time (5 min) nociceptive response. In the ligated RATs, the intensity of PAIN induced by FORMALIN and HISTAMINE was significantly (p<0.05) more than that of non-ligated RATs. Intraperitoneal injection of CHLORPHENIRAMINE (5 mg/kg), without any suppressive effect on locomotor activities, significantly (p<0.05) decreased the PAIN induced by sub-plantar injections of FORMALIN and HISTAMINE in both ligated and non-ligated animals. These results suggest that peripheral nerve injury increases the sensitivity to noxious substances. HISTAMINE through its HI receptors may be involved in producing as well as increasing the intensity of pam.

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APA: Copy

TAMADDONFARD, E., & KARAMI, P.. (2011). EFFECT OF CHLORPHENIRAMINE ON PAIN RESPONSE INDUCED BY PLANTAR INJECTION OF FORMALIN AND HISTAMINE IN SCIATIC NERVE-LIGATED AND NON-LIGATED RATS. SCIENTIFIC-RESEARCH IRANIAN VETERINARY JOURNAL, 7(3 (32)), 13-22. SID. https://sid.ir/paper/97420/en

Vancouver: Copy

TAMADDONFARD E., KARAMI P.. EFFECT OF CHLORPHENIRAMINE ON PAIN RESPONSE INDUCED BY PLANTAR INJECTION OF FORMALIN AND HISTAMINE IN SCIATIC NERVE-LIGATED AND NON-LIGATED RATS. SCIENTIFIC-RESEARCH IRANIAN VETERINARY JOURNAL[Internet]. 2011;7(3 (32)):13-22. Available from: https://sid.ir/paper/97420/en

IEEE: Copy

E. TAMADDONFARD, and P. KARAMI, “EFFECT OF CHLORPHENIRAMINE ON PAIN RESPONSE INDUCED BY PLANTAR INJECTION OF FORMALIN AND HISTAMINE IN SCIATIC NERVE-LIGATED AND NON-LIGATED RATS,” SCIENTIFIC-RESEARCH IRANIAN VETERINARY JOURNAL, vol. 7, no. 3 (32), pp. 13–22, 2011, [Online]. Available: https://sid.ir/paper/97420/en

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