SYNTHESIS AND CYTOTOXICITY EVALUATION OF BIOGLASS NANOFIBERS PREPARED BY ELECTROSPINNING PROCESS FOR FABRICATION OF TISSUE ENGINEERING SCAFFOLD

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YAZDANI CHAMZINI IMAN; RAFIENIA MOHAMMAD; MOVAHEDI BEHROOZ; SALEHI HOSSEIN

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Journal: Journal of Advanced Processes in Materials Engineering Year:2015 | Volume:9 | Issue:3 (34) Page(s): 145-154

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Title

SYNTHESIS AND CYTOTOXICITY EVALUATION OF BIOGLASS NANOFIBERS PREPARED BY ELECTROSPINNING PROCESS FOR FABRICATION OF TISSUE ENGINEERING SCAFFOLD

Author(s)

YAZDANI CHAMZINI IMAN | RAFIENIA MOHAMMAD | MOVAHEDI BEHROOZ | SALEHI HOSSEIN | Issue Writer Certificate

Keywords

NANO FIBERSQ2

BIOACTIVE GLASSQ2

TISSUE ENGINEERINGQ2

SOL-GELQ2

Abstract

Each year, thousands of deaths occur while the patients wait for getting new graft. TISSUE ENGINEERING can help solving many of the problems and this consider with placing the cells in a particular tissue in 3D structure called scaffolds, in order to recovery of natural function of organs. In this study BIOACTIVE GLASS (BG) was synthesized by using tetraetyeorthosilicate (TEOS), triethyle phosphate (TEP) and calcium nitrate tetrahydrate (Ca (N03)2.4H20) via SOL-GEL method. Polyvinyl alcohol and cetyltrimethylamrnonium were mixed with nanofiber of BGS to facilitate electro spinning. Then scaffolds calcinated at 600oC and their bioactivity of the samples studied ill simulated body fluid (SBF) and some other different methods. The most effective parameters on electrospinn ing were studied such as voltage, solution feeding rate, needle diameter, distance between needle tip and collector. Regarding the scanning electron microscope images, fibers with a diameter of 300 nm to I J.UTI were prepared. The atomic force microscopy images shown pores about 2 nm on the surface of fibers. Immersion of the scaffolds in SBF and evaluation of them with Fourier transform infrared spectroscopy and X-ray diffraction, indicated the hydroxyapatite peek on the samples. Zeta potential of the BIOACTIVE GLASS was -10.1 mVthat is like bone tissue, therefore it was susceptible for bone cell culture. Concerning the MTT assay by using MG63 cell line, all of the samples did not show cytotoxicity. Thus the BIOACTIVE GLASS NANO FIBERS could able to attach bone cells and form hydroxyapatite on the surface and can be used as scaffolds for TISSUE ENGINEERING.

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APA: Copy

YAZDANI CHAMZINI, IMAN, RAFIENIA, MOHAMMAD, MOVAHEDI, BEHROOZ, & SALEHI, HOSSEIN. (2015). SYNTHESIS AND CYTOTOXICITY EVALUATION OF BIOGLASS NANOFIBERS PREPARED BY ELECTROSPINNING PROCESS FOR FABRICATION OF TISSUE ENGINEERING SCAFFOLD. ADVANCED PROCESSES IN MATERIALS, 9(3 (34)), 145-154. SID. https://sid.ir/paper/172600/en

Vancouver: Copy

YAZDANI CHAMZINI IMAN, RAFIENIA MOHAMMAD, MOVAHEDI BEHROOZ, SALEHI HOSSEIN. SYNTHESIS AND CYTOTOXICITY EVALUATION OF BIOGLASS NANOFIBERS PREPARED BY ELECTROSPINNING PROCESS FOR FABRICATION OF TISSUE ENGINEERING SCAFFOLD. ADVANCED PROCESSES IN MATERIALS[Internet]. 2015;9(3 (34)):145-154. Available from: https://sid.ir/paper/172600/en

IEEE: Copy

IMAN YAZDANI CHAMZINI, MOHAMMAD RAFIENIA, BEHROOZ MOVAHEDI, and HOSSEIN SALEHI, “SYNTHESIS AND CYTOTOXICITY EVALUATION OF BIOGLASS NANOFIBERS PREPARED BY ELECTROSPINNING PROCESS FOR FABRICATION OF TISSUE ENGINEERING SCAFFOLD,” ADVANCED PROCESSES IN MATERIALS, vol. 9, no. 3 (34), pp. 145–154, 2015, [Online]. Available: https://sid.ir/paper/172600/en

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