The Therapeutic Effect of Amniotic Mesenchymal Stem Cell Transplantation in Type-1 Diabetes

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Rostampour Soosan; EDALATPANAH YADOLAH; Enayati parvar Fariba; HAGHIGHI REZA

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Paper Information

Journal: JOURNAL OF ANIMAL BIOLOGY Year:2019 | Volume:11 | Issue:3 Page(s): 21-31

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Title

The Therapeutic Effect of Amniotic Mesenchymal Stem Cell Transplantation in Type-1 Diabetes

Author(s)

Rostampour Soosan | EDALATPANAH YADOLAH | Enayati parvar Fariba | HAGHIGHI REZA | Issue Writer Certificate

Keywords

Stem cell transplantationQ1

AmnionQ1

Type-1 diabetic modelQ1

Diabetes treatmentQ1

Abstract

Diabetes mellitus can occur due to insulin deficiency or environmental tissues resistance to insulin with the reduction of insulin secretion. The present study aimed to investigate the therapeutic effect of amniotic mesenchymal Stem cell transplantation in the treatment of type 1 diabetes. This study was of experimental type and the animals were divided into four groups including the control or healthy, the diabetic control group, the group receiving cells with the medium, and the group receiving only supernatant soup. Glucose and blood insulin levels and animal weight were studied by ANOVA and t-test during the study. With the first stage of Stem cell transplantation, a significant reduction was found in the animal blood glucose of both groups receiving cell and medium (p = 0. 004) and the group receiving supernatant soup (p = 0. 014) than the control group. Such results were not observed after the second stage. The insulin levels had no statistically significant difference. The present study indicated that the repeated transplantation of Amniotic Mesenchymal stem cells can decrease the blood glucose but increase the blood insulin level and the injection of supernatant soup alone be solely effective as much as the cell transplantation.

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APA: Copy

Rostampour, Soosan, EDALATPANAH, YADOLAH, Enayati parvar, Fariba, & HAGHIGHI, REZA. (2019). The Therapeutic Effect of Amniotic Mesenchymal Stem Cell Transplantation in Type-1 Diabetes. JOURNAL OF ANIMAL BIOLOGY, 11(3 ), 21-31. SID. https://sid.ir/paper/176936/en

Vancouver: Copy

Rostampour Soosan, EDALATPANAH YADOLAH, Enayati parvar Fariba, HAGHIGHI REZA. The Therapeutic Effect of Amniotic Mesenchymal Stem Cell Transplantation in Type-1 Diabetes. JOURNAL OF ANIMAL BIOLOGY[Internet]. 2019;11(3 ):21-31. Available from: https://sid.ir/paper/176936/en

IEEE: Copy

Soosan Rostampour, YADOLAH EDALATPANAH, Fariba Enayati parvar, and REZA HAGHIGHI, “The Therapeutic Effect of Amniotic Mesenchymal Stem Cell Transplantation in Type-1 Diabetes,” JOURNAL OF ANIMAL BIOLOGY, vol. 11, no. 3 , pp. 21–31, 2019, [Online]. Available: https://sid.ir/paper/176936/en

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