The Effect of the HydroAlcoholic Extract of Berberis Integerrima on the Basic Tension of Isolated Tracheal Smooth Muscle and the Interaction of its Effect on the Adrenergic Eystem

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Afrazian Mahya sadat; Bahaodini Aminolah

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Journal: JOURNAL OF ANIMAL BIOLOGY Year:2019 | Volume:11 | Issue:3 Page(s): 13-20

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Title

The Effect of the HydroAlcoholic Extract of Berberis Integerrima on the Basic Tension of Isolated Tracheal Smooth Muscle and the Interaction of its Effect on the Adrenergic Eystem

Author(s)

Afrazian Mahya sadat | Bahaodini Aminolah | Issue Writer Certificate

Keywords

Adrenergic systemQ1

Isolated tracheaQ1

Berberis integerrimaQ1

Smooth musclesQ1

Abstract

Plants are used as pharmaceutical sources in the health system of various countries in the world. Berberis integerrima contains vitamin C and polyphenol. Based on previous studies, vitamin C plays a role in the bronchoconstriction of muscles. Thus, this study attempted to evaluate the effect of this extract on level of tracheal muscle tension. Since the sympathetic nervous system plays a role in the relaxation of tracheal muscles and the substances in this plant are likely to play such a role, the present study investigated the interaction of the effect of extract with the Adrenergic system. A number of 14 male rats were kept in an animal room under normal conditions. Each of them was anesthetized by intraperitoneal injection of 1/2 g/kg of urethane, divided into 3 mm rings, and then placed in a tissue floating bath (containing Krebs solution). The tissues were connected to a power transducer which was also connected to a bridge amplifier with the function of amplifying the signal. Then, the data were recorded by a system called Power lab. Ultimately, they were compared using Independent-sample T test. The effective dose of the extract was obtained as 80 mg/kg. This dose was added to the tissues and then epinephrine and propranolol were added respectively. Findings: A significant reduction was observed in tracheal rings tension in the presence of the extract in comparison to the control group. Such an effect was fixed even after adding epinephrine as the agonist of the Adrenergic system and propranolol as the agonist of β 2 receptor. The hydro alcoholic extract of Berberis integerrima affects the tension of tracheal smooth muscle and loosens it. This effect interacts with the adrenergic pathway while such an interaction is not probably through β 2 receptors.

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APA: Copy

Afrazian, Mahya sadat, & Bahaodini, Aminolah. (2019). The Effect of the HydroAlcoholic Extract of Berberis Integerrima on the Basic Tension of Isolated Tracheal Smooth Muscle and the Interaction of its Effect on the Adrenergic Eystem. JOURNAL OF ANIMAL BIOLOGY, 11(3 ), 13-20. SID. https://sid.ir/paper/176938/en

Vancouver: Copy

Afrazian Mahya sadat, Bahaodini Aminolah. The Effect of the HydroAlcoholic Extract of Berberis Integerrima on the Basic Tension of Isolated Tracheal Smooth Muscle and the Interaction of its Effect on the Adrenergic Eystem. JOURNAL OF ANIMAL BIOLOGY[Internet]. 2019;11(3 ):13-20. Available from: https://sid.ir/paper/176938/en

IEEE: Copy

Mahya sadat Afrazian, and Aminolah Bahaodini, “The Effect of the HydroAlcoholic Extract of Berberis Integerrima on the Basic Tension of Isolated Tracheal Smooth Muscle and the Interaction of its Effect on the Adrenergic Eystem,” JOURNAL OF ANIMAL BIOLOGY, vol. 11, no. 3 , pp. 13–20, 2019, [Online]. Available: https://sid.ir/paper/176938/en

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