COATING OF GELATIN THIN LAYER FOR SURFACE MODIFICATION OF POLY-CAPROLACTONE FILM

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KHORRAMNEZHAD M.; AKBARI B.; KHARRAZIHA M.

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Journal: Journal of Applied Research in Chemistry Year:2018 | Volume:11 | Issue:4 Page(s): 5-12

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Title

COATING OF GELATIN THIN LAYER FOR SURFACE MODIFICATION OF POLY-CAPROLACTONE FILM

Author(s)

KHORRAMNEZHAD M. | AKBARI B. | KHARRAZIHA M. | Issue Writer Certificate

Keywords

POLYCAPROLACTONEQ2

SURFACE MODIFICATIONQ1

PHYSICAL ENTRAPMENTQ1

GELATINQ1

FILMQ2

Abstract

Poly-caprolactone (PCL) has been widely used as scaffolding material for tissue engineering applications due to its good biocompatibility and suitable mechanical properties. However, lack of suitable surface functional groups is one of limitations related to cell attachment of this material. In this work, GELATIN was coated on the surface of PCL FILMs using PHYSICAL ENTRAPMENT process. Polymeric solution (acetic acid- 5%wt PCL) was cast in a glassy mold then mold remained under vacuum for 24 hours in order to evaporate acetic acid and create of FILM. The composition of water- acetone system (water is dissolving GELATIN and acetone is swelling the surface of the FILM) is the critical point in performance of the PHYSICAL ENTRAPMENT process; so different composition was made and GELATIN was dissolved in them. PCL FILM was immersed in each GELATIN solutions for different times. In order to improve the attachment of the GELATIN on the surface of PCL, chemical crosslinking was done by glutaraldehyde solution. Quality of coating layer was evaluated by using Attenuated Total Reflection–Fourier Transform Infrared spectroscopy (ATR-FTIR). Thickness of PCL FILM and GELATIN coating was estimated by Scanning electron microscopy (SEM). Contact angle measurement (Sessile drop) was done to analysis surface wettability before and after coating process. Mechanical properties also measured by strip tensile test. Results showed that amount of entrapped GELATIN increased by increase of acetone in GELATIN solvent. Mechanical strength increased to two fold also young modulus and elongation improved about 50% due to SURFACE MODIFICATION. In addition SURFACE MODIFICATION improved wettability.

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APA: Copy

KHORRAMNEZHAD, M., AKBARI, B., & KHARRAZIHA, M.. (2018). COATING OF GELATIN THIN LAYER FOR SURFACE MODIFICATION OF POLY-CAPROLACTONE FILM. JOURNAL OF APPLIED RESEARCHES IN CHEMISTRY (JARC), 11(4 ), 5-12. SID. https://sid.ir/paper/179989/en

Vancouver: Copy

KHORRAMNEZHAD M., AKBARI B., KHARRAZIHA M.. COATING OF GELATIN THIN LAYER FOR SURFACE MODIFICATION OF POLY-CAPROLACTONE FILM. JOURNAL OF APPLIED RESEARCHES IN CHEMISTRY (JARC)[Internet]. 2018;11(4 ):5-12. Available from: https://sid.ir/paper/179989/en

IEEE: Copy

M. KHORRAMNEZHAD, B. AKBARI, and M. KHARRAZIHA, “COATING OF GELATIN THIN LAYER FOR SURFACE MODIFICATION OF POLY-CAPROLACTONE FILM,” JOURNAL OF APPLIED RESEARCHES IN CHEMISTRY (JARC), vol. 11, no. 4 , pp. 5–12, 2018, [Online]. Available: https://sid.ir/paper/179989/en

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