RAPID DETECTION AND SENSITIVE DETERMINATION OF LEVODOPA IN PHARMACEUTICAL AND BIOLOGICAL SAMPLES USING SOLID-PHASE EXTRACTION FOLLOWED BY ION MOBILITY SPECTROMETRY

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MOHAMMADNEJAD M.; ANSARI N.

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Journal: Journal of Applied Research in Chemistry Year:2018 | Volume:11 | Issue:4 Page(s): 101-109

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Title

RAPID DETECTION AND SENSITIVE DETERMINATION OF LEVODOPA IN PHARMACEUTICAL AND BIOLOGICAL SAMPLES USING SOLID-PHASE EXTRACTION FOLLOWED BY ION MOBILITY SPECTROMETRY

Author(s)

MOHAMMADNEJAD M. | ANSARI N. | Issue Writer Certificate

Keywords

LEVODOPAQ1

ION MOBILITY SPECTROMETRYQ1

MAGNETIC IRON GRAPHENE NANOCOMPOSITEQ1

URINE SAMPLEQ1

Abstract

LEVODOPA is a precursor of the neurotransmitter dopamine used in the treatment of Parkinson’s disease. Determination of this drug in biological samples is very important for monitoring of its therapeutic effect. In this study, corona discharge ION MOBILITY SPECTROMETRY (IMS) was applied as a rapid and efficient method for determination of this drug in different samples. Injection and oven temperatures, gas flow rate and corona voltage were optimized as experimental parameters influencing both detection and determination efficiencies. By this method, LEVODOPA was determined with low detection limit (1.17 ng. ml-1) in very short time and good recoveries (96.3-98.6%) without needing any complicated preparation and organic solvents. For selective and sensitive determination of LEVODOPA in URINE SAMPLE, LEVODOPA was extracted using a MAGNETIC IRON GRAPHENE NANOCOMPOSITE as a solid phase. The proposed method shows a solid phase extraction procedure followed by IMS can be successfully applied for the simple, inexpensive, rapid, and sensitive determination of drug compounds in biological samples.

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APA: Copy

MOHAMMADNEJAD, M., & ANSARI, N.. (2018). RAPID DETECTION AND SENSITIVE DETERMINATION OF LEVODOPA IN PHARMACEUTICAL AND BIOLOGICAL SAMPLES USING SOLID-PHASE EXTRACTION FOLLOWED BY ION MOBILITY SPECTROMETRY. JOURNAL OF APPLIED RESEARCHES IN CHEMISTRY (JARC), 11(4 ), 101-109. SID. https://sid.ir/paper/179992/en

Vancouver: Copy

MOHAMMADNEJAD M., ANSARI N.. RAPID DETECTION AND SENSITIVE DETERMINATION OF LEVODOPA IN PHARMACEUTICAL AND BIOLOGICAL SAMPLES USING SOLID-PHASE EXTRACTION FOLLOWED BY ION MOBILITY SPECTROMETRY. JOURNAL OF APPLIED RESEARCHES IN CHEMISTRY (JARC)[Internet]. 2018;11(4 ):101-109. Available from: https://sid.ir/paper/179992/en

IEEE: Copy

M. MOHAMMADNEJAD, and N. ANSARI, “RAPID DETECTION AND SENSITIVE DETERMINATION OF LEVODOPA IN PHARMACEUTICAL AND BIOLOGICAL SAMPLES USING SOLID-PHASE EXTRACTION FOLLOWED BY ION MOBILITY SPECTROMETRY,” JOURNAL OF APPLIED RESEARCHES IN CHEMISTRY (JARC), vol. 11, no. 4 , pp. 101–109, 2018, [Online]. Available: https://sid.ir/paper/179992/en

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