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Information Journal Paper

Title

HIGH YIELD SYNTHESIS OF PHENYTOIN UNDER GREEN CONDITIONS

Pages

  27-32

Abstract

 5, 5-Diphenylimidazolidine-2,4-dione, known as PHENYTOIN, is an anticonvulsant drug which is useful in the treatment of grand mal and psychomotor seizures. We herein report a facile, safe and improved protocol for high yield preparation of PHENYTOIN by using a green solvent (water). Benzil, which is prepared from the condensation of two moles of benzaldehyde in the presence of catalytic amounts of thiamine (vitamin B1), is the primary substance for this preparation. The procedure is then followed by using Cu (II) ions and ammonium nitrate for oxidation of benzoin to benzil. PHENYTOIN is finally prepared in 83% yield from benzil and urea in the presence of 30% w/v sodium hydroxide. The purity of the recrystallized. product is verified by experiments based on the USP pharmacopoeia.

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    APA: Copy

    MOJTAHEDI, M.M., & NAJARZADEH, Z.. (2013). HIGH YIELD SYNTHESIS OF PHENYTOIN UNDER GREEN CONDITIONS. JOURNAL OF APPLIED RESEARCHES IN CHEMISTRY (JARC), 7(2), 27-32. SID. https://sid.ir/paper/180036/en

    Vancouver: Copy

    MOJTAHEDI M.M., NAJARZADEH Z.. HIGH YIELD SYNTHESIS OF PHENYTOIN UNDER GREEN CONDITIONS. JOURNAL OF APPLIED RESEARCHES IN CHEMISTRY (JARC)[Internet]. 2013;7(2):27-32. Available from: https://sid.ir/paper/180036/en

    IEEE: Copy

    M.M. MOJTAHEDI, and Z. NAJARZADEH, “HIGH YIELD SYNTHESIS OF PHENYTOIN UNDER GREEN CONDITIONS,” JOURNAL OF APPLIED RESEARCHES IN CHEMISTRY (JARC), vol. 7, no. 2, pp. 27–32, 2013, [Online]. Available: https://sid.ir/paper/180036/en

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