Effect of cross-linking on the release rate and kinetics of fluconazole drug from polyvinyl alcohol film

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Afrashi M.; SEMNANI D.; TALEBI Z.

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Journal: Journal of Applied Research in Chemistry Year:2020 | Volume:13 | Issue:4 Page(s): 5-15

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Title

Effect of cross-linking on the release rate and kinetics of fluconazole drug from polyvinyl alcohol film

Author(s)

Afrashi M. | SEMNANI D. | TALEBI Z. | Issue Writer Certificate

Keywords

Poly-(vinyl alcohol)Q1

Drug delivery systemQ1

Solvent castingQ1

Cross-linkingQ1

Abstract

In this study, a polymer film of poly-(vinyl alcohol) made by solvent/casting method was used to prepare the drug release system for fluconazole. The Cross-linking of polymer films was done by thermal method. The formation of a possible reaction between the polymer and the drug was observed by FT-IR and there was no chemical reaction between polyvinyl alcohol and fluconazole. The rate of drug release in PBS was investigated by spectrophotometric method. The results showed that the drug release rate in the cross-linked film was lower than the non-crosslinked sample, so that in the cross-linked sample, about 95% of the drug was released within 60 min, while the release rate of non-cross-linked sample was reduced to 30 min. Furthermore, the XRD test indicated that the fluconazole was loaded amorphous in PVA film. The mechanism and kinetics of the release of the samples were evaluated and it was found that the mechanism of fluconazole release from the polyvinyl alcohol films in all cases was Fickian and its release rate followed the first-order model. The polymer film can be used locally for loading and releasing fluconazole and decreases the side effects of oral usage of the drug.

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APA: Copy

Afrashi, M., SEMNANI, D., & TALEBI, Z.. (2020). Effect of cross-linking on the release rate and kinetics of fluconazole drug from polyvinyl alcohol film. JOURNAL OF APPLIED RESEARCHES IN CHEMISTRY (JARC), 13(4 ), 5-15. SID. https://sid.ir/paper/180154/en

Vancouver: Copy

Afrashi M., SEMNANI D., TALEBI Z.. Effect of cross-linking on the release rate and kinetics of fluconazole drug from polyvinyl alcohol film. JOURNAL OF APPLIED RESEARCHES IN CHEMISTRY (JARC)[Internet]. 2020;13(4 ):5-15. Available from: https://sid.ir/paper/180154/en

IEEE: Copy

M. Afrashi, D. SEMNANI, and Z. TALEBI, “Effect of cross-linking on the release rate and kinetics of fluconazole drug from polyvinyl alcohol film,” JOURNAL OF APPLIED RESEARCHES IN CHEMISTRY (JARC), vol. 13, no. 4 , pp. 5–15, 2020, [Online]. Available: https://sid.ir/paper/180154/en

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