SYNTHESIS AND CHARACTERIZATION OF TIO2-MGO MESOPOROUS PARTICLES USING COPOLYMERS AS A DRUG DELIVERY SYSTEM FOR SIMVASTATIN

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HABIBI MAHBOUBEH; AGHABOZORG HAMID REZA; TARLANI ALIAKBAR; ABEDI ANITA

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Journal: Journal of Applied Research in Chemistry Year:2018 | Volume:12 | Issue:2 Page(s): 131-140

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Title

SYNTHESIS AND CHARACTERIZATION OF TIO2-MGO MESOPOROUS PARTICLES USING COPOLYMERS AS A DRUG DELIVERY SYSTEM FOR SIMVASTATIN

Author(s)

HABIBI MAHBOUBEH | AGHABOZORG HAMID REZA | TARLANI ALIAKBAR | ABEDI ANITA | Issue Writer Certificate

Keywords

THITANIAQ1

SILICA MESOPOROUS PARTICLESQ1

PSQ1

PVP COPOLYMERQ1

PEOQ1

PPOQ1

PEO COPOLYMERQ1

SIMVASTATINQ1

Abstract

In this study, TiO2-MgO mesoporous particles were prepared via evaporationinducedself assembly method using two different copolymers of polyvinylpyridine-polystyrene(PVP-PS) and polyethylene glycol-polypropylene glycol-polyethylene glycol (PEG-PPG-PEO orPEO-PPO-PEO) as structure directing agents. The characteristics of the products were investigatedby X-ray diffraction (XRD), nitrogen adsorption-desorption isotherm (BET-BJH), Fourier transforminfrared spectrometry (FT-IR), and scanning electron microscopy (SEM). The effects of polymertype, different amounts of magnesium, and calcination temperature were studied. The resultsshowed that the use of (PEO-PPO-PEO) copolymer and increasing the amount of magnesiumnitrate increased the surface area of the products. In addition, increasing of calcination temperaturefrom 400 to 550 oC leads to a reduction in surface area of the samples. SIMVASTATIN was loaded onthe prepared samples and drug release was studied in simulated gastrointestinal fluid. The releaseprofile of SIMVASTATIN fluid from the TiO2-MgO sample, prepared by using (PEO-PPO-PEO), in thesimulated gastric and intestinal within 20 hours showed 100 and 70%, respectively.

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APA: Copy

HABIBI, MAHBOUBEH, AGHABOZORG, HAMID REZA, TARLANI, ALIAKBAR, & ABEDI, ANITA. (2018). SYNTHESIS AND CHARACTERIZATION OF TIO2-MGO MESOPOROUS PARTICLES USING COPOLYMERS AS A DRUG DELIVERY SYSTEM FOR SIMVASTATIN. JOURNAL OF APPLIED RESEARCHES IN CHEMISTRY (JARC), 12(2 ), 131-140. SID. https://sid.ir/paper/180173/en

Vancouver: Copy

HABIBI MAHBOUBEH, AGHABOZORG HAMID REZA, TARLANI ALIAKBAR, ABEDI ANITA. SYNTHESIS AND CHARACTERIZATION OF TIO2-MGO MESOPOROUS PARTICLES USING COPOLYMERS AS A DRUG DELIVERY SYSTEM FOR SIMVASTATIN. JOURNAL OF APPLIED RESEARCHES IN CHEMISTRY (JARC)[Internet]. 2018;12(2 ):131-140. Available from: https://sid.ir/paper/180173/en

IEEE: Copy

MAHBOUBEH HABIBI, HAMID REZA AGHABOZORG, ALIAKBAR TARLANI, and ANITA ABEDI, “SYNTHESIS AND CHARACTERIZATION OF TIO2-MGO MESOPOROUS PARTICLES USING COPOLYMERS AS A DRUG DELIVERY SYSTEM FOR SIMVASTATIN,” JOURNAL OF APPLIED RESEARCHES IN CHEMISTRY (JARC), vol. 12, no. 2 , pp. 131–140, 2018, [Online]. Available: https://sid.ir/paper/180173/en

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