EVALUATION OF THE SERUM IL-17 AND IL-23 LEVELS IN HELICOBACTER PYLORI-INFECTED PEPTIC ULCER PATIENTS

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JAFARZADEH A.A.; MIRZAEI V.; NEMATI M.; REZAYATI M.T; AHMAD BEYGI H.

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Journal: JOURNAL OF MICROBIAL BIOTECHNOLOGY Year:2009 | Volume:1 | Issue:2 (2) Page(s): 31-36

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Title

EVALUATION OF THE SERUM IL-17 AND IL-23 LEVELS IN HELICOBACTER PYLORI-INFECTED PEPTIC ULCER PATIENTS

Author(s)

Keywords

HELICOBACTER PYLORIQ2

PEPTIC ULCERQ3

IL-17Q3

IL-23Q3

Abstract

Background and Objective: H.pylori is a major etiologic agent for several gastroduoedenal diseases including gastric ulcer and PEPTIC ULCER. It has been reported that the Th17 cells strongly associated with inflammatory disease and IL-23 presented as a main inducer of Th17 cells development. The aim of this study was to investigate the serum levels of IL-17 and IL-23 in H. pylori-infected PEPTIC ULCER (PU) patients and H. pylori-infected asymptomatic (AS) carriers.Materials and Methods: Totally, 45 H. pylori-infected PU patients, 30 H. pylori-infected AS carriers and 15 healthy uninfected subjects (as a control group) were enrolled to study. A blood sample was obtained from all participants and the serum levels of IL-17 and IL-23 was measured by ELISA method. Results: The mean serum levels of IL-17 in total PU patients (9.28 pg/ml ± 5.48) was significantly higher than those observed in total AS subjects (5.19 pg/ml ± 3.75, p<0.001) and healthy control group (3.55 pg/ml ± 3.76, p<0.0001) .The mean serum levels of IL-23 in PU, AS and control groups were 8.66 pg/ml ± 8.41, 7.25 pg/ml ± 5.66 and 3.64 pg/ml ± 3.36, respectively .The mean serum levels of IL-23 in PU and AS groups was significantly higher than those found in uninfected control group (P<0.02 and P<0.03, respectively). Conclusion: The results of the present study showed higher serum concentrations of IL-17 and IL-23 in H.pylori-infected subjects as compared with control group.

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APA: Copy

JAFARZADEH, A.A., MIRZAEI, V., NEMATI, M., REZAYATI, M.T, & AHMAD BEYGI, H.. (2009). EVALUATION OF THE SERUM IL-17 AND IL-23 LEVELS IN HELICOBACTER PYLORI-INFECTED PEPTIC ULCER PATIENTS. JOURNAL OF MICROBIAL BIOTECHNOLOGY, 1(2 (2)), 31-36. SID. https://sid.ir/paper/181406/en

Vancouver: Copy

JAFARZADEH A.A., MIRZAEI V., NEMATI M., REZAYATI M.T, AHMAD BEYGI H.. EVALUATION OF THE SERUM IL-17 AND IL-23 LEVELS IN HELICOBACTER PYLORI-INFECTED PEPTIC ULCER PATIENTS. JOURNAL OF MICROBIAL BIOTECHNOLOGY[Internet]. 2009;1(2 (2)):31-36. Available from: https://sid.ir/paper/181406/en

IEEE: Copy

A.A. JAFARZADEH, V. MIRZAEI, M. NEMATI, M.T REZAYATI, and H. AHMAD BEYGI, “EVALUATION OF THE SERUM IL-17 AND IL-23 LEVELS IN HELICOBACTER PYLORI-INFECTED PEPTIC ULCER PATIENTS,” JOURNAL OF MICROBIAL BIOTECHNOLOGY, vol. 1, no. 2 (2), pp. 31–36, 2009, [Online]. Available: https://sid.ir/paper/181406/en

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