STUDY OF THE EFFECT OF PIOGLITAZONE ON TESTICULAR FUNCTION AFTER SCROTAL HEAT INDUCED SHOCK IN THE RAT

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MOHAMMAD HOSEINI S.; NESHAT GHARAMALEKI M.; SAFAVI E.

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Journal: VETERINARY CLINICAL PATHOLOGY (VETERINARY JOURNAL TABRIZ) Year:2015 | Volume:9 | Issue:1 (33) Page(s): 11-22

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Title

STUDY OF THE EFFECT OF PIOGLITAZONE ON TESTICULAR FUNCTION AFTER SCROTAL HEAT INDUCED SHOCK IN THE RAT

Author(s)

MOHAMMAD HOSEINI S. | NESHAT GHARAMALEKI M. | SAFAVI E. | Issue Writer Certificate

Keywords

SCROTAL HEAT SHOCKQ2

TESTISQ2

PIOGLITAZONEQ2

RATQ2

Abstract

Testicular heat shock even for a single short period can induce destruction in testicular tissue and disturbances spermatogenesis. PIOGLITAZONE is an anti-inflammatory and anti-oxidative drug which is used widely in diabetic patients. The main aim of this study is evaluation of effect of PIOGLITAZONE on testicular tissue after SCROTAL HEAT SHOCK. For this purpose, 54 male Wistar RATs were randomly divided in to 9 of 6 RATs. In the first three groups which were used as control, the scrotum of animals were submerged in 230c water. In the other three groups (treatment 1), the scrotum was submerged in 430c water for 15 minutes and then the animals received normal saline for 15, 30 and 60 days. In the final three groups (treatment 2) after SCROTAL HEAT SHOCK induction, PIOGLITAZONE was injected at a dose of 20 mg/kg for 15, 30 and 60 days. At the end of the experimental periods, testicular tissue samples were obtained for pathological and histomorphometerical studies. The results were analyzed with one-way ANOVA and Tukey test and p<0.05 was considered significant. In treatment 1 group the diameter of seminiferous epithelial tubules and epithelial thickness significantly decreased (p<0.05), but interstitial tissue and testicular capsules thickness significantly increased in comparison to control group (p<0.05). In treatment 2 groups, the diameter of seminiferous tubules on the 15th, 30th and 60th days and tubular epithelial thickness on the 30th and 60th days significantly increased (p<0.05) and interstitial tissue thickness on the 15th, 30th and 60th days were significantly decreased in comparison to treatment 1 groups (p<0.05). Testicular capsule significantly decreased in thickness only on the 60th day (p<0.001). The result of this study confirmed that PIOGLITAZONE decreased the destructive effects of heat shock on testicular tissue and significantly improved the testicular histomorphometrical induces.

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APA: Copy

MOHAMMAD HOSEINI, S., NESHAT GHARAMALEKI, M., & SAFAVI, E.. (2015). STUDY OF THE EFFECT OF PIOGLITAZONE ON TESTICULAR FUNCTION AFTER SCROTAL HEAT INDUCED SHOCK IN THE RAT. VETERINARY CLINICAL PATHOLOGY (VETERINARY JOURNAL TABRIZ), 9(1 (33)), 11-22. SID. https://sid.ir/paper/183274/en

Vancouver: Copy

MOHAMMAD HOSEINI S., NESHAT GHARAMALEKI M., SAFAVI E.. STUDY OF THE EFFECT OF PIOGLITAZONE ON TESTICULAR FUNCTION AFTER SCROTAL HEAT INDUCED SHOCK IN THE RAT. VETERINARY CLINICAL PATHOLOGY (VETERINARY JOURNAL TABRIZ)[Internet]. 2015;9(1 (33)):11-22. Available from: https://sid.ir/paper/183274/en

IEEE: Copy

S. MOHAMMAD HOSEINI, M. NESHAT GHARAMALEKI, and E. SAFAVI, “STUDY OF THE EFFECT OF PIOGLITAZONE ON TESTICULAR FUNCTION AFTER SCROTAL HEAT INDUCED SHOCK IN THE RAT,” VETERINARY CLINICAL PATHOLOGY (VETERINARY JOURNAL TABRIZ), vol. 9, no. 1 (33), pp. 11–22, 2015, [Online]. Available: https://sid.ir/paper/183274/en

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