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Information Journal Paper

Title

PROTECTIVE EFFECTS OF GINGER (ZINGIBER OFFICINALE) RHIZOME EXTRACT ON HEAT-INDUCED TESTICULAR DAMAGE IN THE MOUSE

Pages

  183-192

Abstract

 Infertility is a complicated problem with medical significance. Ginger as a medicinal herb is used to treat a number of diseases such as sexual weakness. The aim of this study was to evaluate the effects of ginger rhizome extract on heat-induced testicular damage in the mouse. Fourty male MICE were randomly divided into 4 equal groups including: 1- Control, 2- heat stressed, 3 and 4- stressed and treated with GINGER EXTRACT (1.5 and 3 mg/animal/day). The scrotum of experimental MICE was immersed for 20 min in a water bath at 42oC. Control MICE were similarly treated except that the water bath was maintained at 23oC. MICE were euthanized after 50 days. Blood samples were collected for analysis of testosterone levels. Testes were removed for histopathological assessment and oxidant/antioxidant status. Heat stress significantly reduced blood testosterone level and increased lipid peroxidation product and decreased antioxidant activities of superoxide dismutase, catalase and glutathione peroxidase (p<0.01). GINGER EXTRACT significantly increased blood testosterone level and decreased TESTIS malondialdehyde level and increased antioxidant enzymes activities (p<0.05). Histopathological observations showed progressive degeneration after HEATING. In the MICE treated with GINGER EXTRACT, testes had normal spermatogenesis and structure. The results indicated that GINGER EXTRACT improves spermatogenesis and oxidative damage of TESTIS induced by heat stress in the mouse.

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    APA: Copy

    AMOUOGHLI TABRIZI, B., & KHAKPOUR, M.. (2013). PROTECTIVE EFFECTS OF GINGER (ZINGIBER OFFICINALE) RHIZOME EXTRACT ON HEAT-INDUCED TESTICULAR DAMAGE IN THE MOUSE. VETERINARY CLINICAL PATHOLOGY (VETERINARY JOURNAL TABRIZ), 7(3 (27)), 183-192. SID. https://sid.ir/paper/183094/en

    Vancouver: Copy

    AMOUOGHLI TABRIZI B., KHAKPOUR M.. PROTECTIVE EFFECTS OF GINGER (ZINGIBER OFFICINALE) RHIZOME EXTRACT ON HEAT-INDUCED TESTICULAR DAMAGE IN THE MOUSE. VETERINARY CLINICAL PATHOLOGY (VETERINARY JOURNAL TABRIZ)[Internet]. 2013;7(3 (27)):183-192. Available from: https://sid.ir/paper/183094/en

    IEEE: Copy

    B. AMOUOGHLI TABRIZI, and M. KHAKPOUR, “PROTECTIVE EFFECTS OF GINGER (ZINGIBER OFFICINALE) RHIZOME EXTRACT ON HEAT-INDUCED TESTICULAR DAMAGE IN THE MOUSE,” VETERINARY CLINICAL PATHOLOGY (VETERINARY JOURNAL TABRIZ), vol. 7, no. 3 (27), pp. 183–192, 2013, [Online]. Available: https://sid.ir/paper/183094/en

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